金属有机骨架载体固定化生物酶的研究进展  

Research Progress on Immobilization of Biological Enzymes on Metalorganic Framework Carriers

作　　者：张帅[1] 王悦[1] 王艳[1] 赵宁[1] 张娜[1] 辛嘉英[1] ZHANG Shuai;WANG Yue;WANG Yan;ZHAO Ning;ZHANG Na;XIN Jiaying(Key Laboratory for Food Science and Engineering,Harbin University of Commerce,Harbin 150076,China)

机构地区：[1]哈尔滨商业大学,食品科学与工程重点实验室,黑龙江哈尔滨150076

出　　处：《食品工业科技》2022年第2期463-471,共9页Science and Technology of Food Industry

基　　金：国家自然科学基金项目(21573055);哈尔滨商业大学青年创新人才项目青年后备人才专项(2019CX33);2019年度中央支持地方高校改革发展资金人才培养项目;黑龙江省自然科学基金项目(LH2020F008)。

摘　　要：金属有机骨架(Metal-Organic Frameworks, MOFs)是金属中心与有机配体通过配位作用自组装形成的多孔晶态材料。MOFs具有稳定性强、大比表面积、高孔隙率、可重复使用等特点,作为一种新型固定化载体材料,具有广泛的应用前景。本文主要从MOFs载体固定化生物酶的合成方法、MOFs-生物酶复合材料的特性和应用等方面进行总结分析,并对MOFs载体固定化生物酶的将来研究方向进行了展望,为后续开发研究和在生物与医药行业应用提供了理论依据。Metal-Organic Frameworks(MOFs) are porous crystalline materials formed by self-assembly of metal centers and organic ligands through coordination. MOFs have the characteristics of strong stability, large specific surface area, high porosity, and reusability. As a new type of immobilized carrier material, it has a wide range of application prospects. In this article, the synthesis method of biological enzyme immobilized on MOFs carrier is mainly summarized and analyzed, the characteristics and application of MOFs-biological enzyme composite material, and the future research direction of the synthetic method of enzyme immobilized on MOFs carrier are prospected. A theoretical basis would be provided for the development research and applications in the biological and pharmaceutical industries.

关 键 词：金属有机骨架 固定化酶 共固定化 金属有机骨架-生物酶复合材料 

分 类 号：Q814.2[生物学—生物工程]