Neuroprotective agents effective against radiation damage of central nervous system  

作　　者：Mária Lalkovičová 

机构地区：[1]Laboratory of Radiation Biology,Joint Institute for Nuclear Research,Dubna,Russia [2]Slovak Academy of Sciences,Institute of Experimental Physics,Košice,Slovakia

出　　处：《Neural Regeneration Research》2022年第9期1885-1892,共8页中国神经再生研究（英文版）

摘　　要：Ionizing radiation caused by medical treatments,nuclear events or even space flights can irreversibly damage structure and function of brain cells.That can result in serious brain damage,with memory and behavior disorders,or even fatal oncologic or neurodegenerative illnesses.Currently used treatments and drugs are mostly targeting biochemical processes of cell apoptosis,radiation toxicity,neuroinflammation,and conditions such as cognitive-behavioral disturbances or others that result from the radiation insult.With most drugs,the side effects and potential toxicity are also to be considered.Therefore,many agents have not been approved for clinical use yet.In this review,we focus on the latest and most effective agents that have been used in animal and also in the human research,and clinical treatments.They could have the potential therapeutical use in cases of radiation damage of central nervous system,and also in prevention considering their radioprotecting effect of nervous tissue.

关 键 词：ANTIOXIDANTS biomedical neuroprotectants central nervous system ionizing radiation neuroprotection radiation injury radiomitigators radioprotectants RADIOPROTECTION THERAPEUTICS 

分 类 号：R818.05[医药卫生—放射医学]