Neuronal circuitry reconstruction after stem cell therapy in damaged brain  

作　　者：Daniel Tornero 

机构地区：[1]Department of Biomedical Sciences,Institute of Neuroscience and Production and Validation Center of Advanced Therapies(Creatio),University of Barcelona [2]August Pi I Sunyer Biomedical Research Institute(IDIBAPS) [3]Network Center for Biomedical Research in Neurodegenerative Diseases(CIBERNED),Barcelona,Spain

出　　处：《Neural Regeneration Research》2022年第9期1959-1960,共2页中国神经再生研究（英文版）

基　　金：supported by Ministerio de Ciencia e Innovación(Spain),under project No.PID2020-118120RB-I00;European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No.813851;European Union’s FET-Open program grant agreement,No.9648877(to DT).

摘　　要：Transplantation of neuronal precursors derived from human pluripotent stem cells is a promising therapy for the treatment of neurological disorders associated with neuronal loss,such us neurodegenerative diseases,brain trauma and stroke.The functional integration of grafted neurons differentiated from stem cells into the host injured neuronal circuitry has been a major challenge in cell therapy strategies for brain repair(Palma-Tortosa et al.,2021).Even though other cell types or mechanisms may provide modest clinical improvements,neuronal replacement and reconstruction of the damaged area are crucial for an optimal and long-term recovery.

关 键 词：DISEASES damaged 

分 类 号：R741.05[医药卫生—神经病学与精神病学]