PGE2联合LBP水平对肝硬化失代偿期患者发生感染的预测价值  

Predictive value of serum PGE2 on the infection of patients with decompensated liver cirrhosis

作　　者：陈文晓[1] 陈柳 张艳[1] 黄慧峰[1] 吴振兴[1] 盛显仓 CHEN Wen-xiao;CHEN Liu;ZHANG Yan;HUANG Hui-feng;WU Zhen-xing;SHENG Xian-cang(Department of Gastroenterology,Taizhou first people's Hospital,Taizhou 318020,Zhejiang,China)

机构地区：[1]台州市第一人民医院消化内科,浙江318020

出　　处：《肝脏》2021年第12期1353-1355,共3页Chinese Hepatology

基　　金：台州市科学技术局项目(1801ky69)。

摘　　要：目的分析肝硬化失代偿期患者前列腺素E2(PGE2)水平对患者感染发生的预测价值。方法选取2016年3月至2018年3月期间在台州市第一人民医院治疗的66例肝硬化失代偿期患者,根据是否发生感染分为感染组(23例)和未感染组(43例),再将同期收治的40例代偿期肝硬化患者设为对照组,分别检测三组患者的血清PGE2水平,分析PGE2水平对肝硬化失代偿期患者感染发生的预测价值。结果感染组(3686.87±232.25)及未感染组(2132.03±120.04)患者血清PGE2水平与对照组(1348.97±87.58)相比明显更高(P<0.05);感染组血清PGE2水平与未感染组相比明显更高(P<0.05);PGE2水平预测肝硬化失代偿期患者感染发生的ROC曲线下面积为0.84(95%CI为0.74~0.90),有统计学意义(P<0.01);预测肝硬化失代偿期患者PGE2水平为2758 pg/mL时,其感染发生的特异度为0.785、灵敏度为0.829。结论肝硬化失代偿期患者PGE2水平与感染的发生具有密切关系,PGE2水平对预测肝硬化失代偿期患者感染发生的特异度、敏感度较高。Objective To analyze the predictive value of serum prostaglandin E2(PGE2)on the occurrence of infection in patients with decompensated liver cirrhosis.Methods Sixty-six patients with decompensated liver cirrhosis admitted from March 2016 to March 2018 were selected.The patients were divided into an infection group(n=23)and a non-infection group(n=43)according to whether they had the occurrence of infection.Another 40 patients with compensated liver cirrhosis treated at the same period of time were selected as the control group.Serum PGE2 levels were measured in all three groups of patients.The predictive value of PGE2 levels on the occurrence of infection in patients with decompensated liver cirrhosis was analyzed.Results The PGE2 levels in the infection group(3686.87±232.25 pg/mL)and the non-infection group(2132.03±120.04 pg/mL)were significantly higher than that in the control group(1348.97±87.58)(P<0.05),and the level in the infection group was higher than that in the non-infection group(P<0.05).The area under the receiver operating characteristic curve(ROC)of PGE2 level to predict the occurrence of infection in patients with decompensated liver cirrhosis was 0.84(95%CI=0.74-0.90),which was statistically significant(P<0.01).When the cut-off value of PGE2 level was set at 2758 pg/mL,the specificity for predicting the occurrence of infection was 0.785,and the sensitivity was 0.829.Conclusion The level of PGE2 in patients with decompensated liver cirrhosis is closely related to the occurrence of infection.PGE2 level has higher specificity and sensitivity for predicting infection occurrence in patients with decompensated liver cirrhosis.

关 键 词：肝硬化 失代偿期 PGE2 感染 预测价值 

分 类 号：R575.2[医药卫生—消化系统]