Is intestinal metaplasia the point of no return in the progression of gastric carcinogenesis?  

作　　者：Si-Ran Wu Yu-Hao Liu Yong-Quan Shi 

机构地区：[1]State Key Laboratory of Cancer Biology,National Clinical Research Center for Digestive Diseases,Xijing Hospital,Air Force Medical University,Xi’an,Shaanxi,China [2]Department of Gastroenterology,Chinese Armed Police Force Fujian Armed Police Corps hospital,Fuzhou,Fujian,China [3]First Cadet Regiment,School of Basic Medicine,Air Force Medical University,Xi’an,Shaanxi,China

出　　处：《Chinese Medical Journal》2021年第24期2965-2967,共3页中华医学杂志（英文版）

基　　金：supported by grants from Shaanxi Foundation for Innovation Team of Science and Technology(No.2018TD-003);Project from State Key Laboratory of Cancer Biology(No.CBSKL2019ZZ07)。

摘　　要：Gastric cancer(GC)is one of the most common malignant tumors worldwide.In China,GC is the second most common malignant tumor,and it is the second leading cause of cancer mortality.[1]Correa model showed that the development of intestinal-type GC was a consecutive cancerous process including normal gastric mucosa,non-atrophic gastritis,atrophic gastritis(AG),intestinal metaplasia(IM),dysplasia and intestinal-type GC in sequence.[2]Epithelium-resembling intestinal morphology replaced gastric mucosa which was defined as IM.[3]Among these precancerous conditions,IM was demonstrated to be a vital risk factor for GC,especially incomplete IM and extensive IM.[4,5].

关 键 词：GASTRITIS GASTRIC METAPLASIA 

分 类 号：R735.2[医药卫生—肿瘤]