Differential diagnosis of multiple primary lung cancers and intra-lung metastasis of lung cancer by multiple gene detection  

作　　者：Liuyang Xu Jin Chen Yupeng Zeng Xiao Li Zhihong Zhang 

机构地区：[1]Department of Pathology,The First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China [2]The Fourth Clinical Medical College of Nanjing Medical University,Nanjing,Jiangsu 210029,China

出　　处：《Chinese Medical Journal》2022年第1期86-88,共3页中华医学杂志（英文版）

基　　金：This study was supported by a grant from the National Natural Science Foundation of China(No.81773109)。

摘　　要：A global trend towards greater health awareness with a resulting reduction in smoking has contributed to the improved control and early detection of lung cancer.[1]Furthermore,developments in diagnostic technologies have enhanced the detection of multifocal lung cancer,characterized by multiple cancerous lesions.Multifocal lung cancer can be divided into multiple primary lung cancer(MPLC)and pulmonary metastasis-associated lung cancer intrapulmonary metastases(IM)according to the types of lesions.The differential diagnosis of MPLC and IM is clinically important because of the direct impacts on tumor-node-metastasis staging and the implications for the treatment of lung cancer.The diagnostic criteria for MPLC were first proposed by Martini and Melamed in 1975[2]and were subsequently revised and supplemented by the American College of Chest Physicians(ACCP)in 2003.[3]These ACCP standards currently provide the main diagnostic criteria for the clinical differential diagnosis of MPLC and IM.MPLC and IM differ in terms of their clonal origins,which could provide a useful basis for multi-gene detection to assist the diagnosis of multifocal lung cancer.

关 键 词：DIAGNOSIS METASTASIS ACCP 

分 类 号：R734.2[医药卫生—肿瘤]