Anti-tumor effects and cellular mechanisms of Pistacia atlantica methanolic extract against Ehrlich solid tumor in mice  

作　　者：Aishah E.Albalawi Norah A.Althobaiti Reem Hasaballah Alhasani Sultan F.Alnomasy 

机构地区：[1]Faculty of Science,Department of Biology,University of Tabuk,Tabuk 47913,Saudi Arabia [2]Biology Department,College of Science and Humanities,Al Quwaiiyah,Shaqra University,Al Quwaiiyah 19257,Saudi Arabia [3]Department of Biology,Faculty of Applied Science,Umm Al-Qura University,Makkah,Saudi Arabia [4]Department of Medical Laboratories Sciences,College of Applied Medical Sciences,Al-Quwayiyah,Shaqra University,Riyadh,Saudi Arabia

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2022年第2期69-77,共9页亚太热带生物医学杂志（英文版）

摘　　要：Objective:To assess the anti-tumor effects of Pistacia atlantica methanolic extract(PAME)compared with cyclophosphamide against Ehrlich solid tumors in mice.Methods:Swiss albino mice(n=40)were divided into five groups:normal control mice,mice with Ehrlich solid tumors treated with normal saline,mice with Ehrlich solid tumors treated with cyclophosphamide intraperitoneally once a day for 14 d,or 50mg/kg or 100 mg/kg PAME orally once a day for 14 d.Tumor growth inhibition,body weight,tumor markers,liver and kidney enzymes,oxidative stress markers,antioxidant enzymes,tumor necrosis factor-alpha level(TNF-α),and apoptosis-regulatory gene expression were evaluated.Results:Treatment of mice bearing Ehrlich solid tumors with PAME at 50 and 100 mg/kg orally significantly decreased tumor volume,body weight,tumor markers,liver and kidney enzymes,oxidative stress markers and TNF-αlevel in comparison with mice with Ehrlich solid tumors receiving normal saline.whereas PAME at 50 and 100 mg/kg/day significantly elevated the level of antioxidant enzymes(P<0.05).Conclusions:Pistacia atlantica methanolic extract has potent antitumor activity in mice.Therefore,the extract might be considered as an alternative anticancer agent against tumors,however,additional studies especially in the clinical setting are required to confirm this finding.

关 键 词：CANCER Ehrlich solid tumors TREATMENT Pistacia atlantica Herbal medicines Natural product in vivo MICE 

分 类 号：R285.5[医药卫生—中药学]