溶酶体与神经退行性疾病  

Lysosomes and neurodegenerative diseases

作　　者：曲莉丽 仓春蕾 QU Lili;CANG Chunlei(School of Basic Medical Sciences,University of Science and Technology of China,Hefei 230026,China)

机构地区：[1]中国科学技术大学基础医学院,合肥230026

出　　处：《生物学杂志》2022年第1期1-10,共10页Journal of Biology

基　　金：国家自然科学基金项目(31770896,31722018)。

摘　　要：溶酶体是真核细胞内发挥降解功能的主要细胞器,它的功能异常与多种疾病密切相关。综述溶酶体与神经退行性疾病相关的研究进展,并重点从溶酶体酶、溶酶体pH调控和V-ATPase、溶酶体膜蛋白、溶酶体的细胞内定位等方面阐述溶酶体功能异常与神经退行性疾病的关系,为理解神经退行性疾病的机制提供新的视角,同时展望以溶酶体为靶点进行神经退行性疾病治疗和药物开发的广阔前景。Lysosomes are the main degradative organelles in eukaryotic cells,and their dysfunction is closely related to many diseases.The current knowledge on the connection between lysosomal dysfunction and neurodegenerative diseases were reviewed with the focus on lysosomal enzymes,pH regulation,lysosomal membrane proteins,and intracellular localization of lysosomes.It provided a new per-spective for understanding the mechanism of neurodegenerative diseases,and also looked forward to the broad prospects for the treat-ment and drug development of neurodegenerative diseases with lysosomes as the target.

关 键 词：溶酶体 神经退行性疾病 溶酶体贮积症 溶酶体酶 溶酶体膜蛋白 

分 类 号：Q244[生物学—细胞生物学] R741[医药卫生—神经病学与精神病学]