二甲胺四环素联合茶多酚对早期种植体周围软组织炎患者牙周指标、炎性因子以及龈沟液RANKL、Shh水平的影响  

Effects of Minocycline Combined with Tea Polyphenols on Periodontal Index,Inflammatory Factors and RANKL,Shh Levels in Gingival Crevicular Fluid of Patients with Early Peri Implant Soft Tissue Inflammation

作　　者：刘亚娟 马庆云[1] 马瑞朝 赵文丽 廖立凡 段风[1] LIU Ya-juan;MA Qing-yun;MA Rui-chao;ZHAO Wen-li;LIAO Li-fan;DUAN Feng(Department of stomatology,The Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyangf Shaanxi,712000,China;Department of stomatology,521 Hospital of Ordnance Industry,Xi'an,Shaanxi,710065,China;Department of General Dentistry,The Third Affiliated Hospital of Xi'an Medical College,Xi'an,Shaanxi,710068,China;Department of Dental implant,Stomatological Hospital of Xi'an Jiaotong University,Xi'an,Shaanxi,710004,China)

机构地区：[1]陕西中医药大学第二附属医院口腔科,陕西咸阳712000 [2]兵器工业五二一医院口腔科,陕西西安710065 [3]西安医学院第三附属医院口腔综合科,陕西西安710068 [4]西安交通大学口腔医院口腔种植科,陕西西安710004

出　　处：《现代生物医学进展》2021年第23期4505-4508,4577,共5页Progress in Modern Biomedicine

基　　金：陕西省重点研发计划项目(2018SF-003)。

摘　　要：目的:探讨二甲胺四环素联合茶多酚对早期种植体周围软组织炎患者牙周指标、炎性因子以及龈沟液核因子-κβ受体活化因子配体(RANKL)、音猬因子(Shh)水平的影响。方法:将106例于我院就诊的早期种植体周围软组织炎患者纳入研究,以信封抽签法分为对照组(n=53,二甲胺四环素治疗)和研究组(n=53,二甲胺四环素联合茶多酚治疗)。对比两组患者治疗前、治疗4周后的牙周指标、炎性因子、疗效以及龈沟液RANKL、Shh水平,记录两组治疗期间不良反应情况。结果:治疗4周后研究组临床总有效率90.57%(48/53)高于对照组73.58%(39/53)(P<0.05)。两组不良反应发生率对比无差异(P>0.05)。两组治疗4周后改良菌斑指数(m PLI)、改良龈沟出血指数(m SBI)、种植体周袋探诊深度(PPD)和血清白介素-1β(IL-1β)、单核细胞趋化蛋白-1(MCP-1)水平以及龈沟液RANKL、Shh水平均下降,且研究组低于对照组(P<0.05)。结论:二甲胺四环素联合茶多酚治疗早期种植体周围软组织炎患者,疗效显著,可有效改善患者牙周情况,降低患者血清IL-1β、MCP-1水平以及龈沟液RANKL、Shh水平,安全可靠。Objective:To investigate the effect of minocycline combined with tea polyphenols on periodontal index,inflammatory factors,gingival crevicular fluid nuclear factor kappaβreceptor activator ligand(RANKL),Hedgehog factor(Shh)levels in patients with early peri implant soft tissue inflammation.Methods:A total of 106 patients with early peri-implant soft tissue inflammation admitted to our hospital were included in this study,they were divided into control group(n=53,treated with minocycline)and study group(n=53,treated with tea polyphenol on the basis of minocycline)by envelope lottery.The periodontal index,curative effect,inflammatory factors,RANKL and Shh levels in gingival crevicular fluid of the two groups before treatment and after 4 weeks of treatment were compared,adverse reactions of the two groups during treatment were recorded.Results:The total clinical effective rate of the study group at 4 weeks after treatment was higher than that of the control group(P<0.05).The modified plaque index(m PLI),modified gingival sulcus bleeding index(m SBI),periimplant pocket depth(PPD),serum interleukin-1β(IL-1β),monocyte chemoattractant protein-1(MCP-1),RANKL and Shh levels in gingival sulcus fluid decreased in the two groups at 4 weeks after treatment,and study group was lower than the control group(P<0.05).There was no significant difference between incidence of adverse reactions of the two groups(P>0.05).Conclusion:Minocycline combined with tea polyphenols in the treatment of patients with early periimplant soft tissue inflammation are significant efficacy,which can effectively improve the periodontal situation of patients,reduce the serum IL-1β,MCP-1 levels and RANKL,Shh levels in gingival crevicular fluid,which is safe and reliable.

关 键 词：二甲胺四环素 茶多酚 种植体周围软组织炎 牙周指标 RANKL SHH 

分 类 号：R781.4[医药卫生—口腔医学] R783[医药卫生—临床医学]