Prediction of Apigenin Targets in Lung Cancer Using Network Pharmacology and Molecular Docking  

作　　者：Xinqiang SONG Yu ZHANG Huanhuan HE Jinke FAN Lei WANG 

机构地区：[1]College of Life Sciences, Xinyang Normal University, Xinyang 464000, China [2]Medical College, Xinyang Normal University, Xinyang 464000, China

出　　处：《Medicinal Plant》2021年第6期28-32,共5页药用植物：英文版

基　　金：the National Natural Science Foundation of China(U1804179);the Henan Science and Technology Innovation Team for Investigation of Plant Resources in Dabie Mountains and the Study and Utilization of Active Components of Special Plants(2017083);the Nanhu Scholars Program for Young Scholars of Xinyang Normal University(2018001).

摘　　要：[Objectives]To elucidate the mechanism of action of apigenin against lung cancer.[Methods]First,drug-target pathways and networks were constructed to predict potential protein targets of apigenin and their main interactions with the drug.Then,the ingenuity pathway analysis(IPA)was carried out to identify enriched gene pathways and networks,and the candidate protein targets of apigenin were predicted using networks and pathways that overlapped between proteins associated with lung cancer and proteins targeted by apigenin.[Results]Docking studies with apigenin indicated that BCL-2,CASP9,CDK2,CYCLIND1,PI3K,NF-κB,Rb1,p53,and AKT are the top candidate targets of apigenin,suggesting that the drug acts against lung cancer by regulating proteins involved in molecular mechanisms of cancer,as well as small cell lung cancer,pancreatic adenocarcinoma,glucocorticoid receptor,and p53 signaling.It was also found that apigenin affects networks mainly involved in the cell cycle,cell-to-cell signaling and interactions,hematological system development and function,cell death and survival,and organismal injury and abnormalities.[Conclusions]This study shows that network pharmacology is useful in generating hypotheses about how apigenin exerts therapeutic effects in lung cancer,as well as in discovering new multitarget drugs against other complex diseases.

关 键 词：APIGENIN Lung cancer Ingenuity pathway analysis(IPA) Network pharmacology DOCKING 

分 类 号：R73[医药卫生—肿瘤]