2982例新生儿疾病筛查可疑阳性病例召回情况分析  

Analysis on the suspicious positive recall in neonatal disease screening of 2982 cases

作　　者：王颖 黄太华[2] 牟鸿江[2] 安露[2] 杨青 卜朴 张莎莎 WANG Ying;HUANG Tai-Hua;MU Hong-Jiang(Guizhou Provincial Maternal and Child Health Care Hospital,Guiyang,Guizhou 550004,China)

机构地区：[1]贵州省妇幼保健院,贵州贵阳550004 [2]贵州省疾病预防控制中心,贵州贵阳550004 [3]铜仁市妇幼保健院保健部基层信息科,贵州铜仁554300

出　　处：《中国妇幼保健》2022年第2期326-329,共4页Maternal and Child Health Care of China

基　　金：贵州省卫生计生委科学技术基金项目(gzwjkj2017-1-088)。

摘　　要：目的分析2018-2019年贵州省新生儿疾病筛查中心先天性甲状腺功能减低症(CH)和苯丙酮尿症(PKU)筛查可疑阳性新生儿召回情况及影响召回的因素,为采取相应的干预措施提供参考依据。方法回顾性分析2018-2019年贵州省新生儿疾病筛查中心CH和PKU的筛查、追访资料,对可疑阳性召回情况和未召回原因进行统计描述及分析。结果 2018-2019年贵州省新生儿疾病筛查中心共筛查新生儿412 850例,筛查出可疑阳性病例2 982例,召回2 783例,总召回率93.33%。共筛查出CH可疑阳性病例2 603例,召回2 441例,召回率93.78%;PKU可疑阳性病例379例,召回342例,召回率90.24%。CH可疑阳性召回率高于PKU,差异有统计学意义(χ^(2)=6.653,P<0.05)。黔东南州、铜仁市及省级医院可疑阳性召回率较高,黔西南州、六盘水市较低,差异有统计学意义(χ^(2)=22.766,P<0.05)。省级医院、县级医院及乡镇卫生院可疑阳性召回率高于市级医院和民营医院,差异有统计学意义(χ^(2)=9.651,P<0.05)。未召回的199例CH和PKU可疑阳性患儿中,以家长拒绝复查或口头同意但一直不复采等主观不配合为主,为114例,占未召回人数的57.29%。结论贵州省新生儿疾病筛查中心可疑阳性新生儿召回工作仍需进一步加强,应加强健康教育和各级妇幼保健机构可疑阳性追访管理,提高可疑阳性召回率。Objective To analyze the recall status of suspicious positive cases and the influencing factors in congenital hypothyroidism(CH) and phenylketonuria(PKU) screening in Guizhou Neonatal Disease Screening Center from 2018 to 2019,provide a reference basis for taking corresponding interventional measures.Methods The screening and follow-up data of CH and PKU in Guizhou Neonatal Disease Screening Center from 2018 to 2019 were analyzed retrospectively,the recall status of suspicious positive cases and non-recall reasons were statistically described and analyzed.Results From 2018 to 2019,412 850 neonates were screened in Guizhou Neonatal Disease Screening Center,2 982 suspicious positive cases were screened out,2 783 suspicious positive cases were recalled,the suspected positive recall rate was 93.33%.There were 2 603 suspicious positive cases of CH,2 441 suspicious positive cases were recalled,the suspected positive recall rate was 93.78%;there were 379 suspicious positive cases of PKU,342 suspicious positive cases were recalled,the suspected positive recall rate was 90.24%.The suspected positive recall rate of CH was statistically significantly higher than that of PKU(χ^(2)=6.653,P<0.05).The suspected positive recall rates in Qiandongnan Prefecture,Tongren City,and provincial level hospitals were higher,the suspected positive recall rates in Qianxi’nan Prefecture and Liupanshui City were lower,there were statistically significant differences(χ^(2)=22.766,P<0.05).The suspected positive recall rates in provincial level hospitals,county level hospitals,and township level hospitals were statistically significantly higher than those in city level hospitals and private hospitals(χ^(2)=9.651,P<0.05).Among 199 non-recall cases of CH and PKU,the main reason was that parents subjectively refused to review,accounting for 57.29%(114 cases).Conclusion The recall of suspicious positive cases needs to be further strengthened in Guizhou Neonatal Disease Screening Center.It is necessary to strengthen health education and manageme

关 键 词：新生儿疾病筛查 可疑阳性 召回 先天性甲状腺功能减低症 苯丙酮尿症 

分 类 号：R715.8[医药卫生—妇产科学]