儿科重症监护病房惊厥性癫痫持续状态患儿预后影响因素分析  

Analysis of prognostic factors in children with convulsive status epilepticus in pediatric intensive care unit

作　　者：庞素玲 李怡静 石宏 蔡慧敏 王松江 PANG Suling;Li Yijing;SHI Hong(Department of Pediatrics,Kaifeng Central Hospital,Kaifeng 475000,Henan China)

机构地区：[1]开封市中心医院儿科,河南开封475000

出　　处：《癫痫与神经电生理学杂志》2022年第1期40-44,共5页Journal of Epileptology and Electroneurophysiology(China)

摘　　要：目的探讨儿科重症监护病房(PICU)中惊厥性癫痫持续状态患儿预后的影响因素。方法收集2016年6月至2020年6月期间在开封市中心医院儿科PICU住院治疗的惊厥性癫痫持续状态患儿96例的临床资料,采用END-IT评价患儿预后情况,分为预后不良组及预后良好组,整理并记录患儿的性别、年龄、病因、抽搐史、全面性发作、生长发育落后、及时安定治疗及PICU住院时间等资料,运用单因素和多因素logistic回归分析探讨上述因素与PICU中惊厥性癫痫持续状态患儿近期预后的关系。结果临床基线资料比较:两组年龄、病因、全面性发作、生长发育落后、PICU住院时间比较差异有统计学意义(P<0.05),多因素logistic回归分析结果显示:年龄(OR=1.253,95%CI:1.076~3.425)、生长发育落后(OR=2.382,95%CI:1.652~8.785)、PICU住院时间(OR=5.576;95%CI:1.253~13.546)是惊厥性癫痫持续状态患儿预后不良的危险因素。而病因、全面性发作方面比较差异无统计学意义(P>0.05)。结论年龄、病因、全面性发作、生长发育落后、PICU住院时间与惊厥性癫痫持续状态患儿预后不良有关,其中年龄、生长发育落后、PICU住院时间是惊厥性癫痫持续状态患儿预后不良的危险因素。Objective To explore the factors affecting the prognosis of children with convulsive status epilepticus in pediatric intensive care unit(PICU).Methods The clinical data of 96 children with convulsive status epilepticus,who were hospitalized in PICU of Kaifeng Central Hospital from June 2016 to June 2020,were collected.The prognosis of the children was evaluated by END-IT.These children were divided into poor prognosis and good prognosis groups.Gender,age,etiology,convulsion history,generalized seizure,retardation of growth and development,timely antipsychotic treatment and the length of hospital stay in PICU were collected and recorded.Univariate and multivariate logistic regression analysis were applied to explore the correlation between the above factors and short-term prognosis of children with status epilepticus in PICU.Results There were statistical differences in age,etiology,general onset,retardation of growth and development,and the length of hospital stay in PICU between two groups(P<0.05).Multivariate logistic regression analysis showed that age(OR=1.253,95%CI:1.076~3.425),retardation of growth and development(OR=2.382,95%CI:1.652~8.785),the length of hospital stay in PICU(OR=5.576;95%CI:1.253~13.546)were risk factors for poor prognosis in children with convulsive status epilepticus.There was no statistically significant differences in etiology and generalized seizures(P>0.05).Conclusion Age,etiology,generalized seizures,retardation of growth and development,the length of hospital stay in PICU are associated with worse prognosis of children with convulsive status epilepticus.Among them,age,retardation of growth and development and length of hospital stay in PICU are risk factors for poor prognosis in children with convulsive status epilepticus.

关 键 词：惊厥性癫痫持续状态 预后 重症监护病房(PICU) 儿童 年龄 生长发育落后 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R72[医药卫生—临床医学]