A nanosystem of copper(II)-disulfiram for cancer treatment with high efficacy and few side effects  

作　　者：Liping ZHAO Xiaoxia WANG Mingxia JIANG Xinghan WU Mogen ZHANG Xiuwen GUAN Jinlong MA Weifen ZHANG 

机构地区：[1]College of Pharmacy,Weifang Medical University,Weifang 261053,China [2]Department of Pathology,Weifang Medical University,Weifang 261053,China [3]School of Clinical Medicine,Weifang Medical University,Weifang 261053,China [4]Collaborative Innovation Center for Target Drug Delivery System,Weifang Medical University,Weifang 261053,China [5]Shandong Engineering Research Center for Smart Materials and Regenerative Medicine,Weifang Medical University,Weifang 261053,China

出　　处：《Frontiers of Materials Science》2021年第4期553-566,共14页材料学前沿（英文版）

基　　金：the National Natural Science Foundation of China(Grant Nos.81774125 and 81973671);the Natural Science Foundation of Shandong Province(Grant No.ZR2019BB071);the Major Innovation and Technology Engineering Project of Shandong Province(Grant No.2019JZZY011106);the Science and Technology Innovation Fund for College Students of Weifang Medical University,and the Weifang Medical University-Sponsored Visiting Schola Research.

摘　　要：Developing chemotherapy drugs with high efficacy and few side effects has been a bottleneck problem that requires an efficient solution.The active cancer treatment ingredient disulfiram(DSF),inspired by the copper(II)diethyldithiocarbamate complex(CuET),can be used in a one-pot synthesis method to construct a CuET delivery nanosystem(CuET-ZIFCu@HA).Due to the high biocompatibility,targeting of CD44 overexpressed cancer cells,and acid response of zeolitic imidazolate framework(ZIF)materials of hyaluronic acid(HA),we realized that CuET-ZIFCu@HA could become an effective and highly selective cancer treatment.Both in vivo and in vitro experiments have demonstrated that CuET-ZIFCu@HA has robust anti-tumor properties without evident side effects.This research provided a promising strategy for DSF nanosystems that involves simple preparation and high efficacy,both of which are key to reusing DSF in cancer treatment.

关 键 词：DISULFIRAM copper(II)diethyldithiocarbamate complex zeolitic imidazolate framework targeted therapy 

分 类 号：TB383[一般工业技术—材料科学与工程] R730.5[医药卫生—肿瘤]