DISULFIRAM

作品数：32被引量：49H指数：4
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相关领域：医药卫生更多>>
相关作者：徐兵周淑芸董慧娟王诗韵陈凯更多>>
相关机构：南方医科大学南方医院南方医科大学暨南大学中国科学院更多>>
相关期刊：《Open Journal of Psychiatry》《Asian Journal of Pharmaceutical Sciences》《Oncology Research》《癌症》更多>>
相关基金：国家自然科学基金广东省科技计划工业攻关项目广东省自然科学基金美国国立卫生研究院基金更多>>
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Inhalable nanoparticles with enhanced cuproptosis and cGAS-STING activation for synergistic lung metastasis immunotherapy被引量：1
《Acta Pharmaceutica Sinica B》2024年第8期3697-3710,共14页Chongzheng Yan Huaiyou Lv Yafei Feng Yuhan Li Zhongxi Zhao 
funded by the Key R&D Programs of Shandong Province,China(Grant Nos.2018CXGC1411 and 2021CXGC010514).
Due to the insufficient Cu^(+)accumulation,Cu^(+)efflux mechanism,and highly immunosuppressive tumor microenvironment(TME)in lung metastasis,the cuproptosis efficacy is limited.Herein,an inhalable nanodevice(CLDCu)is ...
关键词：Cuproptosis cGAS-STING activation DISULFIRAM Inhalation administration Tumor microenvironment PD-L1 checkpoint blockade Lung metastasis IMMUNOTHERAPY 
Disulfiram:A novel repurposed drug for cancer therapy被引量：1
《Chinese Medical Journal》2024年第12期1389-1398,共10页Min Zeng Baibei Wu Wenjie Wei Zihan Jiang Peiqiang Li Yuanting Quan Xiaobo Hu 
supported by grants from the Undergraduate Research and Innovation Project of University of South China(Nos.X202110555528,S202210555245,and X202210555136)
Cancer is a major global health issue.Effective therapeutic strategies can prolong patients’survival and reduce the costs of treatment.Drug repurposing,which identifies new therapeutic uses for approved drugs,is a pr...
关键词：DISULFIRAM Aldehyde dehydrogenase Reactive oxygen species Proteasome activity Cancer stem cells Drug resistance 
Repurposing disulfiram with CuET nanocrystals:Enhancing anti-pyroptotic effect through NLRP3 inflammasome inhibition for treating inflammatory bowel diseases被引量：1
《Acta Pharmaceutica Sinica B》2024年第6期2698-2715,共18页Xueming Xu Yuanfeng Han Jiali Deng Shengfeng Wang Shijie Zhuo Kai Zhao Wenhu Zhou 
supported by National Key Research and Development Program of China(2021YFC2500802);National Natural Science Foundation of China(Nos.82071986,82073799,81771827,82272207,and 82202398);Natural Science Foundation of Hunan Province China(Nos.2021JJ20084 and 2021JJ20090);the Science and Technology Innovation Program of Hunan Province(2021RC3020,China);the Central South University Graduate Students Independent Exploration and Innovation Project(No.2021zzts0984,China);the Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South University(China).
Drug repurposing offers a valuable strategy for identifying new therapeutic applications for existing drugs.Recently,disulfiram(DSF),a drug primarily used for alcohol addiction treatment,has emerged as a potential tre...
关键词：Drug repurposing PYROPTOSIS Nanoparticles BIOAVAILABILITY DISULFIRAM DSS-induced colitis NLRP3 inflammasome CuET 
Combination of disulfiram and CopperCysteamine nanoparticles induces mitochondria damage and promotes apoptosis in endometrial cancer被引量：1
《Bioactive Materials》2024年第6期96-111,共16页Lijun Yang Cancan Yao Zhenning Su Yihao Fang Nil Kanatha Pandey Eric Amador Tian Diao Guo Bao Derong Cao Xihua Chen Xiangbo Xu Bin He Yufeng Zheng Wei Chen 
supported by the National Natural Science Foundation of China(22071066);CAMS Innovation Fund for Medical Science(CIFMS,No.2018-12M-1-004);the project from department of Education,Jiangsu Province for the School of CHIPS at XJTLU(EFP10120240023).
Endometrial cancer(EC)stands as one of the most prevalent gynecological malignancies affecting women,with its incidence and disease-related mortality steadily on the rise.Disulfiram(DSF),an FDA-approved medication pri...
关键词：COMBINATION DISULFIRAM Copper-Cysteamine nanoparticles Mitochondria damage Promotes apoptosis in Endometrial Cancer 
Disulfiram ameliorates STING/MITA-dependent inflammation and autoimmunity by targeting RNF115
《Cellular & Molecular Immunology》2024年第3期275-291,共17页Zhi-Dong Zhang Chang-Rui Shi Fang-Xu Li Hu Gan Yanhong Wei Qianhui Zhang Xin Shuai Min Chen Yu-Lin Lin Tian-Chen Xiong Xiaoqi Chen Bo Zhong Dandan Lin 
supported by grants from the National Key Research and Development Program of China(Grant Nos.2022YFC3401500 and 2023YFC2306100);the Natural Science Foundation of China(Grant Nos.31930040,32070900,82000670,32270951,32200710,and 823B1006);the Fundamental Research Funds for the Central Universities(Grant Nos.2042022kf1187,2042022kf1123 and 2042022dx0003);the Major Scientific and Technological Project of Hubei Province(Grant No.2022ACA005);the Translational Medicine and Interdisciplinary Research Joint Found of Zhongnan Hospital of Wuhan University(Grant.No.ZNJC202218);the Non-Profit Central Research Institute Fund of the Chinese Academy of Medical Sciences(Grant No.2020PT320-004).
STING(also known as MITA)is an adaptor protein that mediates cytoplasmic DNA-triggered signaling,and aberrant activation of STING/MITA by cytosolic self-DNA or gain-of-function mutations causes severe inflammation.Her...
关键词：STING/MITA DISULFIRAM RNF115 SLE AUTOIMMUNITY 
Chemical screening links disulfiram with cardiac protection after ischemic injury被引量：1
《Cell Regeneration》2023年第1期163-173,共11页Yuanyuan Chen Jianyong Du Lixia Zheng Zihao Wang Zongwang Zhang Zhengyuan Wu Xiaojun Zhu Jing-Wei Xiong 
supported by grants from the National Key R&D Program of China(2018YFA0800501 and 2019YFA0801602);the National Natural Science Foundation of China(32230032,31730061,31430059,and 81870198);Shandong Provincial Natural Science Foundation(ZR2022QH394).
Ischemia-reperfusion injury occurs after reperfusion treatment for patients suffering myocardial infarction,however the underlying mechanisms are incompletely understood and effective pharmacological interventions are...
关键词：Small molecule High-throughput chemical screening DISULFIRAM Gasdermin D Ischemia/reperfusion injury Rat cardiomyocytes 
Drug repositioning of disulfiram induces endometrioid epithelial ovarian cancer cell death via the both apoptosis and cuproptosis pathways被引量：6
《Oncology Research》2023年第3期333-343,共11页YAPING GAN TING LIU WEIFENG FENG LIANG WANG LI LI YINGXIA NING 
funded by Guangzhou Scienceand Information Bureau Item of China(Grant No.201904010013);by Natural Science Foundation of Guangdong Province of China(Grant No.2018A0303130180).
Various therapeutic strategies have been developed to overcome ovarian cancer.However,the prognoses resulting from these strategies are still unclear.In the present work,we screened 54 small molecule compounds approve...
关键词：Ovarian cancer Drug repositioning DISULFIRAM APOPTOSIS Cuproptosis 
Disulfiram enhances the antitumor activity of cisplatin by inhibiting the Fanconi anemia repair pathway被引量：1
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2023年第3期207-220,共14页Meng YUAN Qian WU Mingyang ZHANG Minshan LAI Wenbo CHEN Jianfeng YANG Li JIANG Ji CAO 
supported by the National Natural Science Foundation of China(No.82104192);the Zhejiang Provincial Natural Science Foundation(No.LR22H310002);the Scientific Research Fund of Zhejiang University(No.XY2021044);the Zhejiang University K.P.Chao’s High Technology Development Foundation.
A series of chemotherapeutic drugs that induce DNA damage,such as cisplatin(DDP),are standard clinical treatments for ovarian cancer,testicular cancer,and other diseases that lack effective targeted drug therapy.Drug ...
关键词：Disulfiram(DSF) Cisplatin(DDP) DNA damage Fanconi anemia(FA)repair Chemotherapy 
Inhibition of ALDH2 by disulfiram leads to synthetic lethality via ROS strikes twice in ARID1A-deficient cholangiocarcinoma
《Genes & Diseases》2023年第1期69-71,共3页Tingming Liang Lin Jia Rui Duan Lulu Shen Dekang Ren Yujie Ren Yuyang Dou Li Guo 
This work was supported by the National Natural Science Foundation of China(Nos.62171236 and 61771251);the National Natural Science Foundation of Jiangsu,China(No.BK20171443);sponsored by NUPTSF,China(No.NY220041);the Qinglan Project in Jiangsu Province;the Priority Academic Program Development of Jiangsu Higher Education Institution(PAPD),China.
Synthetic lethality describes an interaction whereby the co-occurrence of two mutations leads to cell death but one mutation alone does not,which can be exploited for cancer therapeutics.1 Due to lacking effective non...
关键词：diagnosis mortality ALONE 
Disulfiram, an aldehyde dehydrogenase inhibitor, works as a potent drug against sepsis and cancer via NETosis, pyroptosis, apoptosis, ferroptosis, and cuproptosis被引量：3
《Blood Science》2022年第3期152-154,共3页Dingrui Nie Cunte Chen Yangqiu Li Chengwu Zeng 
This work was supported by grants from the National Natural Science Foundation of China(81770158);Guangdong Science and Technology Project(No.2020A0505100042);the Pearl River S&T Nova Program of Guangzhou,China(No.201906010002)。
Regulated cell death(RCD)is essential for maintaining cell homeostasis and preventing diseases.Besides classical apoptosis,several novel nonapoptotic forms of RCD including NETosis,pyroptosis,ferroptosis,and cuproptos...
关键词：APOPTOSIS Cuproptosis DISULFIRAM Ferroptosis SEPSIS NETosis PYROPTOSIS 
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