Disulfiram, an aldehyde dehydrogenase inhibitor, works as a potent drug against sepsis and cancer via NETosis, pyroptosis, apoptosis, ferroptosis, and cuproptosis  

作　　者：Dingrui Nie Cunte Chen Yangqiu Li Chengwu Zeng 

机构地区：[1]Key Laboratory for Regenerative Medicine of Ministry of Education,Institute of Hematology,School of Medicine,Jinan University,Guangzhou,China

出　　处：《Blood Science》2022年第3期152-154,共3页血液科学（英文）

基　　金：This work was supported by grants from the National Natural Science Foundation of China(81770158);Guangdong Science and Technology Project(No.2020A0505100042);the Pearl River S&T Nova Program of Guangzhou,China(No.201906010002)。

摘　　要：Regulated cell death(RCD)is essential for maintaining cell homeostasis and preventing diseases.Besides classical apoptosis,several novel nonapoptotic forms of RCD including NETosis,pyroptosis,ferroptosis,and cuproptosis have been reported and are increasingly being implicated in various cancers and inflammation.Disulfiram(DSF),an aldehyde dehydrogenase inhibitor,has been used clinically for decades as an anti-alcoholic drug.New studies have shown that DSF possesses potent anti-inflammatory and anti-cancer effects by regulating these new types of RCD.Here,we summarize the mechanisms and discuss the potential application of DSF in the treatment of cancers and inflammatory diseases.

关 键 词：APOPTOSIS Cuproptosis DISULFIRAM Ferroptosis SEPSIS NETosis PYROPTOSIS 

分 类 号：R73[医药卫生—肿瘤]