Decidualization and Related Pregnancy Complications  

作　　者：Jing Tong Shijian Lv Jieqiong Yang Hongwanyu Li Weiya Li Cong Zhang 

机构地区：[1]Center for Reproductive Medicine,Ren Ji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,200135,China [2]Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics,Shanghai,200135,China [3]Shandong Provincial Key Laboratory of Animal Resistance Biology,College of Life Sciences,Shandong Normal University,Jinan,Shandong 250014,China

出　　处：《Maternal-Fetal Medicine》2022年第1期24-35,共12页母胎医学杂志（英文）

基　　金：supported by the National Key R&D Program of China(2019YFA0802600);the National Natural Science Foundation of China(32170863,31871512,and 31671199)to C.Z.Support was also received from grants from the Shanghai Commission of Science and Technology(17DZ2271100);Open Project of Shandong Provincial Key Laboratory of Reproductive Medicine(SDKL2017018).

摘　　要：Decidualization is the differentiation of endometrial stromal cells into secretory decidual stromal cells.Human decidualization involves some amount of signaling molecules and pathways as well as genetic reprogramming,which is driven by the postovulatory rise in progesterone levels and local cyclic adenosine monophosphate production.Decidualization extends from the primary decidual zone to the secondary decidual zone,and then exits through apoptosis.Evidences support that decidual fibroblasts function as the pool of decidual stromal cells during pregnancy.Decidualization undergoes an acute inflammatory phase,an anti-inflammatory secretory phase to the final recession phase.The decidualization of the inner layer of endometrium,termed decidua,is the most critical determinant of pregnancy success,which can promote placenta formation,modulate immune tolerance,foster resistance to oxidative stress,sense embryo quality,and control labor.Failure to adequate decidualization in terms of hormones,biochemistry,and immunology leads to adverse pregnancy outcomes,including diseases such as preeclampsia,miscarriage,premature labor,repeated implantation failures,and some age-related decline in reproductive capacity.The development of animal models and in vitro culture systems combined with emerging technologies provides a powerful system to explore the mechanism of decidualization.However,decidualization is a dynamic,multi-step process,and translating of current research progress into disease predictions and interventions for pregnancy complications remains to be achieved.The study of periodic regeneration and spontaneous decidualization of the endometrium will be beneficial to the diagnosis and treatment of pregnancy diseases.

关 键 词：DECIDUA DECIDUALIZATION Decidual stromal cells Endometrial stromal cells Pregnancy complications 

分 类 号：R714.2[医药卫生—妇产科学]