Renal cell carcinoma and viral infections:A dangerous relationship?  

作　　者：Melissa Bersanelli Chiara Casartelli Sebastiano Buti Camillo Porta 

机构地区：[1]Medical Oncology Unit,University Hospital of Parma,Parma 43126,Italy [2]Department of Medicine and Surgery,University of Parma,Parma 43126,Italy [3]Department of Biomedical Sciences and Human Oncology,University of Bari‘A.Moro’,Bari 70121,Italy [4]Department of Medical Oncology,Policlinico Consorziale,Bari 70124,Italy

出　　处：《World Journal of Nephrology》2022年第1期1-12,共12页世界肾病学杂志（英文版）

摘　　要：Virus-related cancers in humans are widely recognized,but in the case of renal cancer,the link with the world of viruses is not clearly established in humans,despite being known in animal biology.In the present review,we aimed to explore the literature on renal cell carcinoma(RCC)for a possible role of viruses in human RCC tumorigenesis and immune homeostasis,hypothesizing the contribution of viruses to the immunogenicity of this tumor.A scientific literature search was conducted using the PubMed,Web of Science,and Google Scholar databases with the keywords“virus”or“viruses”or“viral infection”matched with(“AND”)“renal cell carcinoma”or“kidney cancer”or“renal cancer”or“renal carcinoma”or“renal tumor”or“RCC”.The retrieved findings evidenced two main aspects testifying to the relationship between RCC and viruses:The presence of viruses within the tumor,especially in non-clear cell RCC cases,and RCC occurrence in cases with pre-existing chronic viral infections.Some retrieved translational and clinical data suggest the possible contribution of viruses,particularly Epstein-Barr virus,to the marked immunogenicity of sarcomatoid RCC.In addition,it was revealed the possible role of endogenous retrovirus reactivation in RCC oncogenesis,introducing new fascinating hypotheses about this tumor’s immunogenicity and likeliness of response to immune checkpoint inhibitors.

关 键 词：Renal cell carcinoma Renal cancer Kidney cancer Viruses Viral infections RETROTRANSPOSONS 

分 类 号：R73[医药卫生—肿瘤]