跨课程PBL教学法在化学小分子设计和优化平台开发中的应用  

Application of Cross-course PBL Teaching Method in the Development of Small Chemical Molecular Design and Optimization Platform

作　　者：胡广 肖飞[1] Hu Guang;Xiao Fei(School of Biology and Basic Medical Sciences,Soochow University,Suzhou 215123,China)

机构地区：[1]苏州大学苏州医学院基础医学与生物科学学院,江苏苏州215123

出　　处：《广东化工》2021年第24期263-264,246,共3页Guangdong Chemical Industry

基　　金：教育部产学合作协同育人项目(202102448005);江苏高校优势学科建设工程。

摘　　要：在后基因组时代背景下,计算机辅助药物发现在现代药物研发中体现越来越重要的作用。它不仅仅是交叉理论学科,涉及到计算机、生物、化工等学科的内容,更具有很强的实践性。因此,本教改论文探讨如何在生物信息学本科专业开展PBL教学,以一个药物设计中具体的问题为导向,将各不同学科中关联课程的知识串联起来,包括从实验流程设计将相关课程的内容以项目内容为导向,将相关知识进行模块化融合,加强知识的融会贯通和实践转化,加深学生对不同学科知识的综合理解,调动学生参与课堂的积极性以及独立思考的主动性,提升学生主动提出问题和解决问题的能力。同时也为类似交叉学科课程的教学和课程设计提供了新的思路。In the post-genomic era, computer-aided drug discovery(CADD) plays a more and more important role in modern drug research and development. It not only belongs to an interdisciplinary theoretical discipline, including the contents of computational, biological, chemical engineering science and so on, but also has strong practicality. Therefore, this educational reform paper this paper discusses how to carry out PBL teaching which is oriented by a specific problem in drug design in the undergraduate major of bioinformatics and connect the knowledge of relevant courses in different subjects, including designing the experimental process to guide the content of relevant courses toward the project aim;modularizing the relevant knowledge and strengthening the integration and practical transformation of knowledge;deepening the students’ comprehensive understanding of the knowledge of different disciplines, mobilizing students’ enthusiasm to participate in the classroom and the initiative of independent thinking;and then improve students’ ability to actively ask and solve problems. It also provides new ideas for the teaching and curriculum design of similar interdisciplinary courses.

关 键 词：计算机辅助药物发现 PBL教学 跨课程 生物信息学 药物设计平台开发 

分 类 号：O6-4[理学—化学] G642[文化科学—高等教育学]