细菌群体感应系统调控及淬灭机制研究进展  

Research Progress on the Regulation and Quenching Mechanisms of Bacterial Quorum Sensing System

作　　者：韩翔鹏 上官文丹 李尧 刘丹 钟青萍[1] Han Xiangpeng;Shangguan Wendan;Li Yao;Liu Dan;Zhong Qingping(Guangdong Provincial Key Laboratory of Food Quality and Safety,College of Food Science,South China Agricultural University,Guangzhou 510642)

机构地区：[1]华南农业大学食品学院,广东省食品质量安全重点实验室,广州510642

出　　处：《中国食品学报》2022年第2期390-401,共12页Journal of Chinese Institute Of Food Science and Technology

基　　金：国家自然科学基金面上项目(31972046);广东省重点领域研发计划项目(2018B020206001);广东省科技计划项目(2020B1212060059)。

摘　　要：细菌利用群体感应系统实现种内和种间信息的交流,调控菌体的生理特性,如生物膜的形成、菌体的运动、毒素的分泌、细菌素及抗生素的产生,群体感应系统贯穿细菌生长繁殖的整个过程,并对细菌群体的稳定性具有重要作用。近年来,越来越多的群体感应系统被发现和深入研究,其调控机制也逐渐清晰,这为群体感应系统更加广泛地应用于实际奠定了基础。本文综述细菌中普遍存在的4种群体感应系统,并对典型菌株的群体感应系统进行重点分析,总结群体感应抑制剂淬灭群体感应系统的作用机制和研究现状,旨在为更加全面且深入探究群体感应系统调控机制以及开发新型抗菌剂提供借鉴。Bacteria utilize quorum sensing system to exchange intraspecific and interspecific information and regulate the physiological characteristics,including the biofilm formation,movement,secretion of toxins,production of bacteriocins and antibiotics.Therefore,quorum sensing system runs through the whole process of bacterial growth and reproduction,and plays an important role in the stability of bacterial population.Recently,more and more quorum sensing systems have been discovered and studied,and their regulatory mechanisms have been elucidated gradually,providing the foundation for the practical application of quorum sensing systems.In this paper,four kinds of bacterial quorum sensing systems were reviewed,and those of typical strains were analyzed.In addition,the quorum-sensing inhibitors and the quorum quenching mechanisms were summarized.The purpose of this paper was to provide a reference for the further study of the regulation mechanism of quorum sensing system and the development of new antibacterial agents.

关 键 词：群体感应 机制 群体感应抑制剂 淬灭 

分 类 号：TS201.3[轻工技术与工程—食品科学]