修饰β-环糊精与非瑟酮包合物的制备及其抗氧化活性研究  

Preparation and Antioxidant Activity of Modifiedβ-Cyclodextrin and Fisetin Inclusion Complex

作　　者：盘振杰 杨敏芬 黄秋萍[1] 张贞发[1] 王强[1] Pan Zhenjie;Yang Minfen;Huang Qiuping;Zhang Zhenfa;Wang Qiang(College of Chemistry and Biological Engineering,Guangxi Normal University for Nationalities,Chongzuo 532200,China)

机构地区：[1]广西民族师范学院化学与生物工程学院,广西崇左532200

出　　处：《云南化工》2022年第1期22-24,共3页Yunnan Chemical Technology

基　　金：广西高校中青年教师基础能力提升项目(No:2020KY20015)。

摘　　要：水溶液法合成β-CD顺丁烯二酸单酯,再与氯化亚砜和N,N′-二(3-氨丙基)乙二胺反应,从而制得N,N′-二(3-氨丙基)乙二胺修饰β-CD(主体)。通过饱和水溶液法制备主体与非瑟酮(客体)的包合物。采用UV、IR等表征并测定主体与客体的结合稳定常数,通过DPPH法测定包合物的抗氧化活性。结果表明,主体与客体的结合稳定常数K_(S)=2.1308×10^(5),包合物对DPPH自由基具有较好的抗氧化活性。β-CD maleic acid monoester was synthesized by aqueous solution method,and then reacted with thionyl chloride and N,N′-bis(3-aminopropyl)ethylenediamine to obtain N,N′-di(3-aminopropyl)ethylenediamine modified β-CD(host),and the inclusion compound of host and fisetin(guest)was prepared by a saturated aqueous solution method.The inclusion compound is characterized by UV,IR,etc.,and the binding stability constant of the host and guest is determined;The antioxidant activity of the inclusion compound is determined by the DPPH method.The results show that the binding stability constant of the host and the guest is K_(S)=2.1308×10^(5);the inclusion compound has good antioxidant activity to DPPH free radicals.

关 键 词：包合物 Β-环糊精 抗氧化活性 非瑟酮 

分 类 号：R96[医药卫生—药理学]