皮肤磷酸化突触核蛋白在路易体痴呆诊断中的应用  

Application of skin phosphorylated synuclein in the diagnosis of dementia with Lewy body

作　　者：李兰珺[1] 杨靖[1] 袁艳鹏 王扬扬[1] 刘晓静[1] 蒋晨阳[1] 许予明[1] Li Lanjun;Yang Jing;Yuan Yanpeng;Wang Yangyang;Liu Xiaojing;Jiang Chenyang;Xu Yuming(Department of Neurology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院神经内科,郑州450052

出　　处：《中华医学杂志》2022年第5期378-381,共4页National Medical Journal of China

基　　金：河南省医学科技攻关计划(联合共建)项目(LHGJ20190077)。

摘　　要：本研究选择2019年8月至2021年3月就诊于郑州大学第一附属医院,临床诊断为路易体痴呆、进行性核上性麻痹、阿尔茨海默病、额颞叶痴呆的患者及健康志愿者各3例。通过皮肤神经微活检,检测路易体痴呆患者皮肤磷酸化α-突触核蛋白的沉积,与其他类型痴呆患者和健康志愿者进行比较。路易体痴呆患者皮肤神经可见线状磷酸化α-突触核蛋白沉积,其他痴呆患者和正常健康人皮肤神经未见沉积。皮肤磷酸化α-突触核蛋白有可能成为路易体痴呆鉴别诊断的生物标志物,仍需大样本研究。Patients with dementia with Lewy body(DLB),Alzheimer disease(AD),frontotemporal dementia(FTP),progressive supranuclear palsy(PSP)and healthy controls in the Department of Neurology,the First Affiliated Hospital of Zhengzhou University from August 2019 to March 2021 were recruited,with 3 in each group.Phosphorylatedα-synuclein from the skin of DLB patients was detected by skin micro-biopsy and compared with patients with AD,FTP,PSP and health controls.Phosphorylatedα-synuclein was found in the skin nerves of the DLB patients,while noα-synuclein were detected in the skin samples of others.Skin phosphorylatedα-synuclein may potentially become a diagnostic biomarker of DLB,however further studies are warranted to assess its sensitivity and specificity.

关 键 词：痴呆 路易体痴呆 皮肤活检 Α-突触核蛋白 诊断 

分 类 号：R749.1[医药卫生—神经病学与精神病学]