肠道微生物在神经系统自身免疫性疾病中的研究进展  

Research progress of gut microbiome in autoimmune diseases of nervous system

作　　者：唐诗 冯金洲[1] 秦新月[1] TANG Shi;FENG Jin-zhou;QIN Xin-yue(Department of Neurology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院神经内科,400016

出　　处：《中国现代神经疾病杂志》2022年第1期17-22,共6页Chinese Journal of Contemporary Neurology and Neurosurgery

基　　金：重庆市科卫联合医学科研项目(项目编号:2020FYYX104)。

摘　　要：肠道微生物是人体最直接的外环境,对维持健康具有重要作用。肠道微生物可维持人体免疫系统稳态,与宿主共生可影响人体营养、代谢和免疫功能。肠道微生物通过免疫系统和内分泌系统与神经系统产生双向联系,即微生物-肠-脑轴。肠道微生物失调引起神经系统及外周异常免疫反应,参与自身免疫性疾病的发病机制。本文综述肠道微生物在多发性硬化、视神经脊髓炎谱系疾病、自身免疫性脑炎、重症肌无力、吉兰-巴雷综合征等经典神经系统自身免疫性疾病中的研究进展。Gut microbiome is the most direct external environment of human body,which plays a vital role in maintaining human health.Gut microbiome maintains the homeostasis of the human immune system,which can coexist with the host and affect the nutrition,metabolism and immune function.Gut microbiome makes a mutual connection with the nervous system through the immune and endocrine systems,namely the"microbe-gut-brain"axis.Gut microbiome disorders can cause abnormal immune responses in the nervous system and the periphery,participating in the pathogenesis of autoimmune diseases.This article reviews the research progress of gut microbiome in multiple sclerosis(MS),neuromyelitis optica spectrum disorders(NMOSDs),autoimmune encephalitis(AE),myasthenia gravis(MG),Guillain-Barrésyndrome(GBS)and other classic autoimmune diseases of the nervous system.

关 键 词：微生物学 肠 神经系统自身免疫疾病 综述 

分 类 号：R741[医药卫生—神经病学与精神病学]