Melatonin and its protective role against male reproductive toxicity induced by heavy metals,environmental pollutants,and chemotherapy:A review  

作　　者：TIECHENG SUN LINGLI SONG JING MA HONG YU SHANJIE ZHOU SHUSONG WANG LI TIAN 

机构地区：[1]Reproductive Medical Center,Department of Obstetrics and Gynecology,Peking University International Hospital,Beijing,102206,China [2]NHC Key Laboratory of Family Planning and Healthy/Key Laboratory of Reproductive Medicine of Hebei Province,Shijiazhuang,050051,China [3]Reproductive Medicine Centre,Peking University Second Affiliated Hospital,Beijing,100044,China

出　　处：《BIOCELL》2020年第4期479-485,共7页生物细胞（英文）

基　　金：from NHC Key Laboratory of Family Planning and Healthy/key laboratory of reproductive medicine of Hebei provincial(SZ-202006);Peking University International Hospital Research Funds(No.YN2019QN13).

摘　　要：Melatonin,as a ubiquitous indoleamine hormone,is synthesized primarily by the pineal gland.It has diverse biological effects through quite complex mechanisms.More recently,studies have focused on the mechanism of melatonin in anti-reproductive toxicity/damage.Since melatonin possesses strong antioxidant and anti-apoptotic properties,researchers have examined its potential role in protecting against male reproductive toxicity/damage,which may be induced by chemotherapy or environmental toxicants and can lead to male infertility.In this article,recent progress regarding the protective effects of melatonin on male reproductive toxicity/damage is reviewed.

关 键 词：MELATONIN Membrane RECEPTORS Heavy metal Environmental TOXICANT Anti-reproductive toxicity 

分 类 号：R73[医药卫生—肿瘤]