Effect of Black Sea bream extracts on cytokine production inlipopolysaccharide-induced inflammation  

作　　者：EUN NA MYOUNGWON CHOI INDAL PARK SUNYOUNG LIM 

机构地区：[1]Ocean Science and Technology School,Korea Maritime&Ocean University,Busan,Korea [2]Department of Microbiology,Kosin University College of Medicine,Busan,Korea [3]Division of Marine Bioscience,Korea Maritime&Ocean University,Busan,Korea

出　　处：《BIOCELL》2020年第2期193-199,共7页生物细胞（英文）

基　　金：Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Science,ICT and Future Planning(NRF-2017R1A2B4005915)。

摘　　要：We investigated the effect of black sea bream extracts on changes in pro-inflammatory and anti-inflammatory cytokines induced by lipopolysaccharide(LPS)in murine splenocytes.The levels of pro-inflammatory cytokines[interleukin(IL)-6,tumor necrosis factor-α(TNF-α),IL-12/IL-23(p40)and IL-17A]and anti-inflammatory cytokines[IL-4,IL-10 and interferon-γ(IFN-γ)]were assessed.Incubation of murine splenocytes with acetone+methylene chloride(A+M)and methanol(MeOH)extracts significantly decreased LPS-induced IL-6,IL-12/IL-23(p40)and IL-17A productions after 6 h incubation(p<0.05).The A+M and MeOH extracts significantly increased LPS-induced IL-4 and IFN-γproductions at 48 and 72 h incubation(p<0.05).Treatment with A+M extract resulted in significantly higher IL-10 production in splenocytes after 72 h(p<0.05).Conclusively,black sea bream extracts were shown to be efficient in falling several pro-inflammatory cytokines while rising anti-inflammatory cytokines.Thus our results suggest that black sea bream extracts selectivity modulate immune events.

关 键 词：Black Sea BREAM CYTOKINES INTERLEUKIN-4 INTERLEUKIN-6 INTERLEUKIN-17A 

分 类 号：R28[医药卫生—中药学]