INTERLEUKIN-17A

作品数：23被引量：85H指数：6
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相关领域：医药卫生更多>>
相关作者：黎丽丁利平黄钟刘冬舟更多>>
相关机构：暨南大学第二临床医学院深圳大学北京大学山东大学更多>>
相关期刊：《International Journal of Dermatology and Venereology》《Journal of Cancer Metastasis and Treatment》《Neural Regeneration Research》《Advances in Precision Medicine》更多>>
相关基金：国家自然科学基金Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry中国博士后科学基金深圳市科技计划项目更多>>
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Interleukin-17A facilitates tumor progression via upregulating programmed death ligand-1 expression in hepatocellular carcinoma
《World Journal of Gastrointestinal Oncology》2025年第1期176-198,共23页Zhong-Xia Yang Li-Ting Zhang Xiao-Jun Liu Xue-Bin Peng Xiao-Rong Mao 
Supported by the Natural Science Foundation of Gansu Province,No.21JR7RA373 and No.24JRRA295.
BACKGROUND Hepatocellular carcinoma(HCC)is an inflammation-associated tumor with a dismal prognosis.Immunotherapy has become an important treatment strategy for HCC,as immunity is closely related to inflammation in th...
关键词：INTERLEUKIN-17A Programmed death ligand-1 Interleukin-17A receptor Small mothers against decapentaplegic 2 Hepatocellular carcinoma IMMUNOTHERAPY 
Spinal astrocyte-derived interleukin-17A promotes pain hypersensitivity in bone cancer mice
《Acta Pharmaceutica Sinica B》2024年第12期5249-5266,共18页Huizhu Liu Xuejing Lv Xin Zhao Lanxing Yi Ning Lv Wendong Xu Yuqiu Zhang 
supported by National Natural Science Foundation of China(31930042 and 82021002);STI 2030-Major Projects(2021ZD0203200-5,China)and by funds from the innovative research team of high-level local universities in Shanghai,Shanghai Municipal Science and Technology Major Project(No.2018SHZDZX01,China),ZJLab and Shanghai Center for Brain Science and Brain-Inspired Technology.
Spinal microglia and astrocytes are both involved in neuropathic and inflammatory pain,which may display sexual dimorphism.Here,we demonstrate that the sustained activation of spinal astrocytes and astrocyte-derived i...
关键词：ASTROCYTE MICROGLIA INTERLEUKIN-17A Sex difference Chemogenetic manipulation Optogenetic manipulation Bone cancer pain Spinal cord 
Effects of Lycium barbarum polysaccharide on cytokines in adolescents with subthreshold depression:a randomized controlled study
《Neural Regeneration Research》2024年第9期2036-2040,共5页Xiaoyue Li Tao Liu Xuan Mo Runhua Wang Xueyan Kong Robin Shao Roger S.Mclntyre Kwok-Fai So Kangguang Lin 
supported by the National Natural Science Foundation of China,No.81671347(to KL);the Science and Technology Program of Guangzhou of China,No.202007030012(to KFS and KL);the Science and Technology Program of Guangzhou of China,No 202102020735(to RW).
Strong evidence has accumulated to show a correlation between depression symptoms and inflammatory responses.Moreover,anti-inflammatory treatment has shown partial effectiveness in alleviating depression symptoms.Lyci...
关键词：adolescents CYTOKINES EFFICACY Goji berry inflammatory responses INTERLEUKIN-17A Lycium barbarum polysaccharide randomized controlled study subthreshold depression 
Aureane-type sesquiterpene tetraketides as a novel class of immunomodulators with interleukin-17A inhibitory activity被引量：1
《Acta Pharmaceutica Sinica B》2023年第9期3930-3944,共15页Xin Tang Chuanxi Wang Lei Wang Feifei Ren Runqiao Kuang Zhenhua Li Xue Han Yiming Chen Guodong Chen Xiuqing Wu Jie Liu Hengwen Yang Xingzhong Liu Chen Wang Hao Gao Zhinan Yin 
supported by the National Key Research and Development Program of China(2018YFA0903200,2018YFA0903201,and 2020YFA0803502);the National Natural Science Foundation of China(81925037,U22A20371,31830021,32030036,and 82270055);the 111 Project(B16021,China);National High-level Personnel of Special Support Program(2017RA2259,China);Guangdong International Science and Technology Cooperation Base(2021A0505020015,China);Innovative and Research Teams Project of Guangdong Higher Education Institution(2021KCXTD001,China);Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y036,China);Guangdong Natural Science Funds for Distinguished Young Scholar(2021B1515020065,China)。
Interleukin(IL)-17A,a pro-inflammatory cytokine,is a fundamental function in the onset and advancement of multiple immune diseases.To uncover the primary compounds with IL-17A inhibitory activity,a large-scale screeni...
关键词：Aureane-type sesquiterpene tetraketides IL-17A Experimental autoimmune encephalomyelitis Pulmonary hypertension 
Neutrophil-derived interleukin-17A participates in neuroinflammation induced by traumatic brain injury被引量：6
《Neural Regeneration Research》2023年第5期1046-1051,共6页Xiao-Jian Xu Qian-Qian Ge Meng-Shi Yang Yuan Zhuang Bin Zhang Jin-Qian Dong Fei Niu Hao Li Bai-Yun Liu 
supported by the National Natural Science Foundation of China,No. 81771327 (to BYL);Construction of Central Nervous System Injury Basic Science and Clinical Translational Research Platform;Budget of Beijing Municipal Health Commission 2020, No. PXM2020_026280_000002 (BYL)。
After brain injury, infiltration and abnormal activation of neutrophils damages brain tissue and worsens inflammation, but the mediators that connect activated neutrophils with neuroinflammation have not yet been full...
关键词：immune infiltration innate immunity INTERLEUKIN-17A neurodegenerative disease NEUROINFLAMMATION NEUTROPHILS secondary brain injury transcription factor transcriptome traumatic brain injury 
Fingolimod protects against neurovascular unit injury in a rat model of focal cerebral ischemia/reperfusion injury被引量：5
《Neural Regeneration Research》2023年第4期869-874,共6页Xiao-Yu Zhu Ting-Ting Ma Yang Li Ming-Qi Zhang Liang Zhao Jia Liang Lian-Qiu Min 
supported by grants from the National Natural Science Foundation of China,No.81971231(to JL);Liaoning Revitalization Talents Program,No.XLYC1907178(to JL)。
Recent research on the underlying mechanisms of cerebral ischemia indicates that the neurovascular unit can be used as a novel subject for general surveys of neuronal damage and protein mechanisms.Fingolimod(FTY-720)i...
关键词：astrocyte blood-brain barrier CLAUDIN-5 FTY-720 INTERLEUKIN-17A ischemic stroke neural protection neurovascular unit OCCLUDIN sphingosine-1-phosphate receptor 1 
Pirfenidone ameliorates silica-induced lung inflammation and fibrosis in mice by inhibiting the secretion of interleukin-17A被引量：13
《Acta Pharmacologica Sinica》2022年第4期908-918,共11页Zhu-jie Cao Ying Liu Zhe Zhang Pei-ran Yang Zhao-guo Li Mei-yue Song Xian-mei Qi Zhi-fa Han Jun-ling Pang Bai-cun Li Xin-ri Zhang Hua-ping Dai Jing Wang Chen Wang 
This work was financially supported by the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences[grant number:2018-12M-1-001](to CW);the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences[grant number:2018RC31001](to CW);the National Natural Science Foundation of China(91739107)(to JW).
Silicosis is a global occupational disease characterized by lung dysfunction, pulmonary inflammation, and fibrosis, for which there is a lack of effective drugs. Pirfenidone has been shown to exert anti-inflammatory a...
关键词：SILICOSIS pirfenidone INTERLEUKIN-17A inflammation FIBROSIS 
Knockout of interleukin-17A diminishes ventricular arrhythmia susceptibility in diabetic mice via inhibiting NF-κB-mediated electrical remodeling被引量：1
《Acta Pharmacologica Sinica》2022年第2期307-315,共9页De-sheng Li Gen-long Xue Ji-ming Yang Chang-zhu Li Rui-xin Zhang Tao Tian Zheng Li Ke-wei Shen Yang Guo Xue-ning Liu Jin Wang Yan-jie Lu Zhen-wei Pan 
This work was supported by National Key R&D Program of China(2017YFC1307404 to ZP);National Natural Science Foundation of China(82070344,81870295 to ZP 81861128022 to BY);Heilongjiang Touyan Innovation Team Program and CAMS Innovation Fund for Medical Sciences(CIFMS),2019-I2M-5-078(to BY).
Interleukin-17A(IL-17),a potent proinflammatory cytokine,has been shown to participate in cardiac electrical disorders.Diabetes mellitus is an independent risk factor for ventricular arrhythmia.In this study,we invest...
关键词：diabetes mellitus ventricular arrhythmia IL-17 action potential duration transient outward potassium current sodium current L-type calcium current NF-ΚB 
IL-17 sustains the plasma cell response via p38-mediated Bcl-xL RNA stability in lupus pathogenesis被引量：8
《Cellular & Molecular Immunology》2021年第7期1739-1750,共12页Kongyang Ma Wenhan Du Fan Xiao Man Han Enyu Huang Na Peng Yuan Tang Chong Deng Lixiong Liu Yulan Chen Jingjing Li Shiwen Yuan Qin Huang Xiaoping Hong Dajun Hu Xiaoyan Cai Quan Jiang Dongzhou Liu Liwei Lu 
funded by grants from the National Natural Science Foundation of China(Nos.81771761,91842304,and 81901635);Chongqing International Institute for Immunology(2020YJC10);Sanming Project of Medicine in Shenzhen(SZSM201512019)。
Recent studies have demonstrated a central role for plasma cells in the development of autoimmune diseases,such as systemic lupus erythematosus(SLE).Currently,both the phenotypic features and functional regulation of ...
关键词：Systemic lupus erythematosus(SLE) Plasma cell(PC) AUTOANTIBODY Interleukin-17A(IL-17) 
The Association of Psoriasis and Obesity: Focusing on IL-17A-Related Immunological Mechanisms被引量：1
《International Journal of Dermatology and Venereology》2021年第2期116-121,共6页Cheng Xu Jie Ji Ting Su Hong-Wei Wang Zhong-Lan Su 
National Natural Science Foundation of China(No.81773326)。
Psoriasis is a chronic,recurrent,inflammatory skin disease that is often accompanied by obesity.An increasing amount of research has elucidated the pathophysiological link between psoriasis and obesity.Since 2005,inte...
关键词：INTERLEUKIN-17A OBESITY PSORIASIS 
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