The Association of Psoriasis and Obesity: Focusing on IL-17A-Related Immunological Mechanisms  

作　　者：Cheng Xu Jie Ji Ting Su Hong-Wei Wang Zhong-Lan Su 

机构地区：[1]Department of Dermatology,The First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China [2]State Key Laboratory of Analytical Chemistry for Life Science&Jiangsu Key Laboratory of Molecular Medicine,Medical School,Nanjing University,Nanjing,Jiangsu 210093,China

出　　处：《International Journal of Dermatology and Venereology》2021年第2期116-121,共6页国际皮肤性病学杂志（英文）

基　　金：National Natural Science Foundation of China(No.81773326)。

摘　　要：Psoriasis is a chronic,recurrent,inflammatory skin disease that is often accompanied by obesity.An increasing amount of research has elucidated the pathophysiological link between psoriasis and obesity.Since 2005,interleukin(IL)-17-producing T helper 17 cells and their main effector cytokine IL-17A have been considered to play a critical role in the pathogenesis of psoriasis;the marked effect of biotherapies targeting IL-17A on moderate and severe psoriasis has further established its role in psoriasis.Recent studies have found that obesity induces T helper 17 cells to secrete IL-17A and participate in the pathogenesis of psoriasis.IL-17A may be a crucial element in the association between psoriasis and obesity.This review discusses the association between psoriasis and obesity,with a focus on and the implications regarding the need to treat psoriasis.

关 键 词：INTERLEUKIN-17A OBESITY PSORIASIS 

分 类 号：R758.63[医药卫生—皮肤病学与性病学] R589.2[医药卫生—临床医学]