Fingolimod protects against neurovascular unit injury in a rat model of focal cerebral ischemia/reperfusion injury  

作　　者：Xiao-Yu Zhu Ting-Ting Ma Yang Li Ming-Qi Zhang Liang Zhao Jia Liang Lian-Qiu Min 

机构地区：[1]Department of Neurology,The First Affiliated Hospital of Jinzhou Medical University,Jinzhou,Liaoning Province,China [2]Institution of Life Science,Jinzhou Medical University,Jinzhou,Liaoning Province,China [3]School of Pharmacy,Jinzhou Medical University,Jinzhou,Liaoning Province,China

出　　处：《Neural Regeneration Research》2023年第4期869-874,共6页中国神经再生研究（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China,No.81971231(to JL);Liaoning Revitalization Talents Program,No.XLYC1907178(to JL)。

摘　　要：Recent research on the underlying mechanisms of cerebral ischemia indicates that the neurovascular unit can be used as a novel subject for general surveys of neuronal damage and protein mechanisms.Fingolimod(FTY-720)is a newly developed immunosuppressant isolated from Cordyceps sinensis that exhibits a wide range of biological activities,and has recently attracted much attention for the treatment of ischemic cerebrovascular diseases.In the current research,the role of FTY-720 and its possible mechanisms were assessed from an neurovascular unit perspective using a rat cerebral ischemia model.Our results revealed that FTY-720 markedly decreased infarct volume,promoted neurological function recovery,and weakened the blood-brain barrier permeability of ischemic rats.The protective roles of FTY-720 in ischemic stroke are ascribed to a combination of sphingosin-1-phosphate receptor-1 and reduced expression of sphingosin-1-phosphate receptor-1 in microvessels and reduction of interleukin-17A protein levels.These findings indicate that FTY-720 has promise as a new therapy for neurovascular protection and functional recovery after ischemic stroke.

关 键 词：astrocyte blood-brain barrier CLAUDIN-5 FTY-720 INTERLEUKIN-17A ischemic stroke neural protection neurovascular unit OCCLUDIN sphingosine-1-phosphate receptor 1 

分 类 号：R743.34[医药卫生—神经病学与精神病学]