Effects of Lycium barbarum polysaccharide on cytokines in adolescents with subthreshold depression:a randomized controlled study  

作　　者：Xiaoyue Li Tao Liu Xuan Mo Runhua Wang Xueyan Kong Robin Shao Roger S.Mclntyre Kwok-Fai So Kangguang Lin 

机构地区：[1]Department of Affective Disorders,The Affiliated Brain Hospital of Guangzhou Medical University(Guangzhou Huiai Hospital),Guangzhou,Guangdong Province,China [2]Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China,Guangzhou Medical University,Guangzhou,Guangdong Province,China [3]Department of Psychiatry,The Fifth Affiliated Hospital of Guangzhou Medical University,Guangzhou,Guangdong Province,China [4]Mood Disorders Psychopharmacology Unit,Poul Hansen Family Centre for Depression,University Health Network,Toronto,ON,Canada [5]Department of Psychiatry,University of Toronto,Toronto,ON,Canada [6]Brain and Cognition Discovery Foundation,Toronto,Canada [7]Ministry of Education Joint International Research Laboratory of CNS Regeneration,Jinan University,Guangzhou,Guangdong Province,China [8]Neuroscience and Neurorehabilitation Institute,University of Health and Rehabilitation Sciences,Qingdao,Shandong Province,China

出　　处：《Neural Regeneration Research》2024年第9期2036-2040,共5页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.81671347(to KL);the Science and Technology Program of Guangzhou of China,No.202007030012(to KFS and KL);the Science and Technology Program of Guangzhou of China,No 202102020735(to RW).

摘　　要：Strong evidence has accumulated to show a correlation between depression symptoms and inflammatory responses.Moreover,anti-inflammatory treatment has shown partial effectiveness in alleviating depression symptoms.Lycium barbarum polysaccharide(LBP),derived from Goji berries,exhibits notable antioxidative and anti-inflammatory properties.In our recent double-blinded randomized placebo-controlled trial,we found that LBP significantly reduced depressive symptoms in adolescents with subthreshold depression.It is presumed that the antidepressant effect of LBP may be associated with its influence on inflammatory cytokines.In the double-blinded randomized controlled trial,we enrolled 29 adolescents with subthreshold depression and randomly divided them into an LBP group and a placebo group.In the LBP group,adolescents were given 300 mg/d LBP.A 6-week follow up was completed by 24 adolescents,comprising 14 adolescents from the LBP group(15.36±2.06 years,3 men and 11 women)and 10 adolescents from the placebo group(14.9±1.6 years,2 men and 8 women).Our results showed that after 6 weeks of treatment,the interleukin-17A level in the LBP group was lower than that in the placebo group.Network analysis showed that LBP reduced the correlations and connectivity between inflammatory factors,which were associated with the improvement in depressive symptoms.These findings suggest that 6-week administration of LBP suppresses the immune response by reducing interleukin-17A level,thereby exerting an antidepressant effect.

关 键 词：adolescents CYTOKINES EFFICACY Goji berry inflammatory responses INTERLEUKIN-17A Lycium barbarum polysaccharide randomized controlled study subthreshold depression 

分 类 号：R749.4[医药卫生—神经病学与精神病学]