Piceatannol attenuates streptozotocin-induced type 1 diabetes inmice  

作　　者：MENGSHU ZHAO PINGSHI GAO LIANG TAO JINGJING WEN LEI WANG YUGUO YI YUXIN CHEN JUNSONG WANG XI XU JIANFA ZHANG DAN WENG 

机构地区：[1]School of Environmental and Biological Engineering,Nanjing University of Science&Technology,Nanjing,210094,China [2]Department of Laboratory Medicine,Nanjing Drum Tower Hospital,Nanjing University Medical School,Nanjing,210008,China

出　　处：《BIOCELL》2020年第3期353-361,共9页生物细胞（英文）

基　　金：the National Natural Science Foundation of China under Grant 21677076 and 31970897 to DW;Outstanding Youth Foundation of Jiangsu Province(BK20190093)to DW;Qing Lan Project of Jiangsu Province to DW,the Fundamental Research Funds for the Central Universities No.30919011102 to DW,the Innovative and Entrepreneurial Talent Cultivation(Shuangchuang)Program of Jiangsu Province to DW.

摘　　要：As a natural analog of resveratrol,piceatannol(Pic)exhibits good antioxidant and anti-inflammatory activities in different disease models.However,the role of Pic in type 1 diabetes mousemodel has not been reported yet.In this study,we investigated the in vivo effect of Pic in streptozotocin(STZ)-induced type 1 diabetic mice.Mice were injected with STZ to establish the type 1 diabetesmellitus(T1DM)model.After stable hyperglycemia was achieved,mice were then orally treated with Pic(40 mg/kg b.w.,i.g.)for 30 days.The results indicated that Pic supplementation efficiently alleviated the typical symptoms associated with T1DM,including body weight loss,polydipsia,hyperglycemia,and hypoinsulinemia.Pic treatment also improved the glucose tolerance of STZ-induced diabetic mice.In addition,Pic supplementation markedly decreased the expression of pro-inflammatory molecules TNF-αand IL-6,the expression of endoplasmic reticulum(ER)stress markers GRP78 and CHOP,and the level of oxidative stress in T1DM mice.Moreover,Pic administration also partly reversed the metabolic profiles of STZ-treated mice as detected by 1H Nuclear Magnetic Resonance(NMR)-based metabolomics.Our study suggested that the therapeutic potential of Pic in type 1 diabetes and the anti-diabetic effects of Pic may be associated with its activities to suppress oxidative stress,inflammation,and ER stress.

关 键 词：PICEATANNOL Type 1 DIABETES STREPTOZOTOCIN OXIDATIVE STRESS Inflammation ER STRESS 

分 类 号：R58[医药卫生—内分泌]