碳酸钙纳米粒子制备方法及其在抗肿瘤方面应用的研究进展  

Research progress in preparation of calcium carbonate nanoparticles and t heir antitumor applications

作　　者：金凤 萨出拉 李贤 JIN Feng;SA Chula;LI Xian(The First Clinical Medical College,Inner Mongolia Medical Univers ity,Hohhot 010050;Clinical Research Center,Affiliated H ospital of Inner Mongolia Medical University,Hohhot 010050)

机构地区：[1]内蒙古医科大学第一临床医学院,内蒙古呼和浩特010050 [2]内蒙古医科大学附属医院临床医学研究中心,内蒙古呼和浩特010050

出　　处：《当代医药论丛》2022年第4期29-32,共4页

基　　金：内蒙古医科大学2020年大学生科技创新“英才培育”项目(YCPY20200033);内蒙古医科大学2020-2021年度实验室开放基金指南性项目(2020ZN47)。

摘　　要：碳酸钙(CaCO_(3))纳米粒子(CCNPs)具有高度的多孔性、生物相容性、可生物降解性,且具有pH敏感特性,这使其成为良好的生物药物输送系统的候选物。有研究指出,碳酸钙作为载体应用于医学领域具有很大的潜力。目前,药物纳米粒子已被广泛用于药物的体内控制释放,以保护药物,使其不受酶的影响,最终实现组织或细胞靶向治疗。基于CaCO_(3)的药物传递系统(DDS)或类似的纳米结构,会由于其晶相和形貌的不同而存在表面性质的不同。本文综述了载药CCNPs的制备方法和CCNPs作为癌症药物/基因传递系统的最新应用现状(重点介绍其特性,包括pH敏感性、生物降解性和缓释性能)。Calcium carbonate(CaCO_(3))nanoparticles(CCNPs)are highly porous,biocompatible,biodegradable and pH sensitive,which makes them a good candidate for biological drug delivery systems.It has been pointed out that calcium carbonate as a carrier has great potential in the medical field.Currently,drug nanoparticles have been widely used to control the in vivo release of drugs to protect them from enzyme effects and ultimately achieve tissue or cell targeted therapies.Drug delivery systems(DDS)based on CaCO_(3) or similar nanostructures have different surface properties due to their different crystal phases and morphologies.This review reviews the preparation methods of drug-loaded CCNPs and the recent applications of CCNPs as cancer drug/gene delivery systems(with emphasis on their properties,including pH sensitivity,biodegradation and sustained release).

关 键 词：碳酸钙纳米粒子 药物传递 基因传递 抗肿瘤 

分 类 号：R73[医药卫生—肿瘤]