维生素D及其受体在妇科癌症中的研究进展  

Research advances of vitamin D and its receptor in gynecologic cancer

作　　者：尹俊杨 叶元[1] YIN Junyang;YE Yuan(Department of Gynaecology,Affiliated Hospital of Guilin Medical University,Guangxi Guilin 541001,China)

机构地区：[1]桂林医学院附属医院妇科,广西桂林541001

出　　处：《现代肿瘤医学》2022年第6期1129-1133,共5页Journal of Modern Oncology

基　　金：广西重点研发计划项目(编号:桂科AB17292092)。

摘　　要：在过去的二十几年中,国内外大量的研究是关于维生素D及维生素D受体(vitamin D receptor,VDR)在癌症发生、发展中所起的作用。维生素D的活性代谢产物1,25(OH)_(2)D_(3)除了维持体内矿物质的稳态和骨骼的功能外,还具有抑制细胞增殖、诱导细胞分化、凋亡及免疫调节的作用。近些年,越来越多的研究证据表明,维生素D及VDR在妇科癌症的发病机制中发挥着重要的作用,是研究妇科癌症治疗手段中新的切入点。现本文就维生素D及其受体在妇科恶性肿瘤中的研究现状进行综述。In the past two decades,many studies have been concerned with the regulation mechanism of vitamin D and vitamin D receptor(VDR)in cancer.The 1,25(OH)_(2)D_(3) is an active metabolite of vitamin D.It can not only maintain mineral homeostasis and bone dynamic balance,but also inhibit cell proliferation,induce cell differentiation,apoptosis and immune regulation.In recent years,more and more research evidence shows that vitamin D and VDR play an important role in the pathogenesis of gynecological cancer.It is a new entry point in the study of gynecological cancer treatment.In this paper,the status of vitamin D and its receptors in gynecological malignancies will be reviewed.

关 键 词：维生素D VDR 卵巢癌 宫颈癌 子宫内膜癌 外阴癌 阴道癌 

分 类 号：R737.3[医药卫生—肿瘤]