New treatment for amblyopia based on rules of synaptic plasticity:a randomized clinical trial  

作　　者：Xin Huang Huika Xia Qi Zhang Colin Blakemore Yan Nan Wenyao Wang Jie Gao Spencer S Ng Jing Wen Tiejun Huang Xiaoqing Li Mingliang Pu 

机构地区：[1]Department of Anatomy,School of Basic Medical Sciences,Peking University,Beijing 100083,China [2]Key Laboratory on Machine Perception(Ministry of Education),Peking University,Beijing 100083,China [3]Department of Ophthalmology,Hebei General Hospital,Shijiazhuang 050051,China [4]Department of Biomedical Sciences,City University of Hong Kong,Hong Kong,China [5]Department of Biology,University of California,Los Angeles 90095-7246,USA [6]Department of Computer Science,School of Electrical Engineering and Computer Sciences,Peking University,Beijing 100191,China [7]National Engineering Laboratory for Video Technology,Peking University,Beijing 100871,China [8]Department of Pediatric Ophthalmology,Peking University First Hospital,Beijing 100034,China [9]National Amblyopia and Strabismus Prevention and Treatment Center,Beijing 100034,China

出　　处：《Science China(Life Sciences)》2022年第3期451-465,共15页中国科学（生命科学英文版）

基　　金：supported by the National Basic Research Program of China(2011CB510206,2015CB351806);the National Natural Science Foundation of China(31170986,31571091);Beijing Municipal Science&Technology Commission(Z151100000915070)。

摘　　要：Amblyopia resulting from early deprivation of vision or defocus in one eye reflects an imbalance of input from the eyes to the visual cortex.We tested the hypothesis that asynchronous stimulation of the two eyes might induce synaptic plasticity and rebalance input.Experiments on normal adults showed that repetitive brief exposure of grating stimuli,with the onset of each stimulus delayed by 8.3 ms in one eye,results in a shift in perceptual eye dominance.Clinical studies(Clinical trial registration number:Chi CTR2100049130),using popular 3D movies with similar asynchrony between the two eyes(amblyopic eye stimulated first)to treat anisometropic amblyopia,established that just 10.5 h of conditioning over<3 weeks produced improvement that met criteria for successful treatment.The benefits of asynchronous conditioning accumulate over 20–3045 min sessions,and are maintained for at least 2 years.Finally,we demonstrate that asynchronous binocular treatment alone is more effective than patching only.This novel treatment is popular with children and is some 50 times more efficient than patching alone.

关 键 词：AMBLYOPIA visual cortex STDP synaptic plasticity SED 

分 类 号：R777.44[医药卫生—眼科]