Engineering cerebral folding in brain organoids  

作　　者：Glen Scott Yu Huang 

机构地区：[1]Biological Engineering,College of Engineering,Utah State University,Logan,UT,USA

出　　处：《Neural Regeneration Research》2022年第11期2420-2422,共3页中国神经再生研究（英文版）

基　　金：partially USU's Engineering Undergraduate Research Program;partially NIH NIGMS fund,No.R15GM132877;partially NIH NIGMS fund.No.R35GM143194。

摘　　要：Valuable implement to the animal neurological models:Neurological diseases remain the largest cause of death and disability.The discovery of effective therapies is chiefly hindered by the lack of realistic neurological models.Unlike other tissues,it is infeasible or unethical to access primary human neural samples in bulk.But animal models often fail to replicate the complex human-specific neuronal factors present in vivo.Conventional in vitro cultures lack native three-dimensional(3D)morphologies,polarity,and receptor expression,as well as tissue-level interactions(J ensen et al.,2018).

关 键 词：CEREBRAL DISEASES 

分 类 号：R318[医药卫生—生物医学工程]