TDP-35,a truncated fragment of TDP-43,induces dose-dependent toxicity and apoptosis in flies  

作　　者：Deepak Chhangani Diego E.Rincon-Limas 

机构地区：[1]Department of Neurology,McKnight Brain Institute,and Norman Fixel Institute for Neurological Diseases,University of Florida [2]Department of Neuroscience,Center for Translational Research in Neurodegenerative Disease,Genetics Institute,University of Florida

出　　处：《Neural Regeneration Research》2022年第11期2441-2442,共2页中国神经再生研究（英文版）

基　　金：National Institutes of Health grant R01AG059871(to DERL)。

摘　　要：TAR DNA-binding protein 43(TDP-43)is an essential 414 amino acid protein that regulates multiple aspects of RNA biogenesis,processing,and transport.It localizes primarily in the nucleus,but abnormal translocation and accumulation in the cytosol occur under pathological conditions(Tziortzouda et al.,2021).TDP-43 abnormalities are typical pathological hallmarks of amyotrophic lateral sclerosis(ALS)and frontotemporal lobar degeneration.Mutations in the TDP-43-encoding gene TARDBP cause familial ALS。

关 键 词：DEGENERATION TDP 

分 类 号：R741[医药卫生—神经病学与精神病学]