BDE-47在紫贻贝中的分布、蓄积、消除和毒性效应  

Tissue distribution, accumulation, elimination characteristics and toxicity of 2,2’,4,4’-tetrabromodiphenyl ether in blue mussel

作　　者：耿倩倩 郭萌萌[1] 李风铃[1] 刘晓玉 吴峰 于鑫 翟毓秀[1] 谭志军[1,5,6] GENG Qian-qian;GUO Meng-meng;LI Feng-ling;LIU Xiao-yu;WU feng;YU Xin;ZHAI Yu-xiu;TAN Zhi-jun(Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality,Ministry of Agriculture and Rural Affairs,Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao 266071,China;College of Food Science and Technology,Shanghai Ocean University,Shanghai 201306,China;College of Chemistry and Molecular Engineering,Qingdao University of Science and Technology,Qingdao 266061,China;College of Plant Medicine,Qingdao Agricultural University,Qingdao 266109,China;Pilot National Laboratory for Marine Science and Technology(Qingdao),Qingdao 266071,China;Collaborative Innovation Center of Seafood Deep Processing,Dalian Polytechnic University,Dalian 116034,China)

机构地区：[1]中国水产科学研究院黄海水产研究所,农业农村部水产品质量安全检测与评价重点实验室,山东青岛266071 [2]上海海洋大学食品学院,上海201306 [3]青岛科技大学化学与分子工程学院,山东青岛266061 [4]青岛农业大学植物医学学院,山东青岛266109 [5]青岛海洋科学与技术试点国家实验室,山东青岛266071 [6]大连工业大学,海洋食品精深加工关键技术省部共建协同创新中心,辽宁大连116034

出　　处：《中国环境科学》2022年第3期1385-1393,共9页China Environmental Science

基　　金：山东省自然科学基金资助项目(ZR2020QD093);中国博士后科学基金资助项目(2019M662470,2020T130722);青岛市应用研究项目(2019);中国水产科学研究院基本科研业务费资助项目(2020TD71)。

摘　　要：以紫贻贝(Mytilus galloprovincialis)为试验生物,研究了2,2’,4,4’-四溴联苯醚(BDE-47)在贻贝组织中的分布、生物蓄积和消除动态,并探究BDE-47对贻贝的毒性作用.结果发现:紫贻贝对BDE-47有较强的生物蓄积能力和一定的消除能力,且蓄积具有组织特异性和浓度依赖性,消化腺和鳃是BDE-47蓄积的靶器官.蓄积和消除阶段各组织中BDE-47含量符合一阶非线性累积/衰减模型.0.01~1μg/L暴露浓度下,BDE-47在贻贝各组织中的半衰期为0.68~7.62d,生物富集系数(BCFs)为3217~140970L/Kg.BDE-47暴露引发消化腺和鳃抗氧化防御系统及组织损伤,其中超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量和谷胱甘肽-S-转移酶(GST)活性可作为BDE-47暴露的候选生物标志物.The distribution, bioaccumulation and elimination dynamics of 2,2’,4,4’-tetrabromodiphenyl ether(BDE-47) in mussel(Mytilus galloprovincialis) tissues were studied, and the toxic effects of BDE-47 on mussel were investigated. Results showed that blue mussel had strong bioaccumulation ability and certain elimination ability to BDE-47, and the accumulation was tissue-specific and concentration-dependent. Digestive gland and gill were the target organs where BDE-47 accumulated. The content of BDE-47 in tissues at accumulation or elimination stage accorded with the first-order nonlinear accumulation/attenuation model. The elimination half-life and bioconcentration factors(BCFs) of BDE-47 in mussel tissues were 0.68~7.62 d and 3217~140970 L/Kg under 0.01~1μg/L exposure solution, respectively. BDE-47 exposure induced antioxidant defence system and tissue damages in both digestive gland and gill. Superoxide dismutase(SOD) activity, malondialdehyde(MDA) content and glutathione-S-transferase(GST)activity can be used as candidate biomarkers of BDE-47 exposure.

关 键 词：2 2’ 4 4’-四溴联苯醚(BDE-47) 紫贻贝 组织分布 生物蓄积 消除 毒性 

分 类 号：X174[环境科学与工程—环境科学]