Caffeine Exposure Causes Immune Dysfunction and Intrauterine Growth Restriction Retardation in Rats  

作　　者：ZHANG Wen Zhong SUN Na Na HU Yang CAO Yu Amber Sheeks 

机构地区：[1]Department of Safety Engineering,North China Institute of Science&Technology,Sanhe 065201,Hebei,China [2]Key Laboratory of Food Risk Assessment,Ministry of Health China National Center for Food Safety Risk Assessment,Beijing 100021,China [3]Center for Public Health Surveillance and Information Service,Chinese Center for Disease Control and Prevention,Beijing 102206,China [4]Muskingum University,OH 43762,USA

出　　处：《Biomedical and Environmental Sciences》2022年第2期170-173,共4页生物医学与环境科学（英文版）

基　　金：supported by the National Key Research and Development Program of China[2017YFC1601702];Funding for Basic Scientific Research Operation of Central Universities[3142019002].

摘　　要：This study was conducted to assess the effects of caffeine on the dam and the physical development of rat offspring.Pregnant Sprague-Dawley rats(20 per dose group)were administered caffeine by gavage at 0(control),5,20,and 80 mg/kg body weight(bw)daily from gestational day 6 through lactation using caffeine dissolved in water.The developmental toxicity of caffeine was evaluated.Dams in the 80 mg/kg bw group exhibited splenic atrophy.The litter weights were significantly lower in the 20 and 80 mg/kg bw groups than the untreated control(P<0.05),with a greater reduction in the higher dose group.The number of female offspring was reduced in the 20 and 80 mg/kg bw groups(P<0.05).Some of the offspring were eaten by the dam following birth,which accounted for half of the litters in the 80 mg/kg bw group(P<0.05).Offspring body weight in the 80 mg/kg bw group was lower than that in the control during the lactation period(P<0.05).Exposure to caffeine during pregnancy can cause maternal immune dysfunction and intrauterine growth restriction retardation(IUGR);the developmental toxicity of caffeine varied with gender,as females were more sensitive than males.The no observed adverse effect level was 5 mg/kg bw based on the IUGR.

关 键 词：IMMUNE WEIGHTS OFFSPRING 

分 类 号：R994.4[医药卫生—毒理学]