Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma  

作　　者：Fang Wang Peter Breslin S J Wei Qiu 

机构地区：[1]Department of Surgery and Cancer Biology,Loyola University Chicago Stritch School of Medicine,Maywood,IL,USA [2]Department of Molecular/Cellular Physiology,Cancer Biology,Cardinal Bernardin Cancer Center,Loyola University Medical Center,and Biology,Loyola University Chicago,Chicago,IL,USA

出　　处：《Liver Research》2021年第4期195-203,共9页肝脏研究（英文）

摘　　要：Hepatocellular carcinoma(HCC)is a very deadly disease.HCC initiation and progression involve multiple genetic events,including the activation of proto-oncogenes and disruption of the function of specific tumor suppressor genes.Activation of oncogenes stimulates cell growth and survival,while loss-of-function mutations of tumor suppressor genes result in unrestrained cell growth.In this review,we summarize the new findings that identified novel proto-oncogenes and tumor suppressors in HCC over the past five years.These findings may inspire the development of novel therapeutic strategies to improve the outcome of HCC patients.

关 键 词：Hepatocellular carcinoma(HCC) ONCOGENE Tumor suppressor Activation LOSS-OF-FUNCTION 

分 类 号：R735.7[医药卫生—肿瘤]