STARD1:a new rising StAR in cholesterol-mediated hepatocarcinogenesis  

作　　者：Salvatore Papa Concetta Bubici Wing-Kin Syn 

机构地区：[1]Leeds Institute of Medical Research at St.James’,Faculty of Medicine and Health,University of Leeds,St.James’University Hospital,Leeds,UK [2]Centre for Genome Engineering and Maintenance,Department of Life Sciences,College of Health,Medicine and Life Sciences,Brunel University London,Uxbridge,UK [3]Division of Gastroenterology and Hepatology,Medical University of South Carolina,Charleston,SC,USA [4]Section of Gastroenterology,Ralph H.Johnson Veterans Affairs Medical Center,Charleston,SC,USA [5]Department of Physiology,Faculty of Medicine and Nursing,University of the Basque Country,Universidad del Pais Vasco/Euskal Herriko Unibertsitatea(UPV/EHU),Leioa,Spain

出　　处：《Hepatobiliary Surgery and Nutrition》2021年第6期910-912,共3页肝胆外科与营养（英文）

基　　金：SP and CB acknowledge the research funding from Rosetrees Trust(M894)and Guts UK(DGO2019_02).

摘　　要：Having cholesterol in our body is essential for living healthy,but too much can lead to serious health problems,including-but not limited to-heart attacks and strokes(1).Indeed,accumulating evidence points to cholesterol as a cancer risk factor especially in colon,rectal,prostatic and testicular cancer(2).Cholesterol is the most abundant sterol in animal tissues with many important functions that spans from simply maintaining cell membrane physical properties to the production of bile acids and biosynthesis of steroid hormones.For the most part,cholesterol is synthetised de novo in the liver,but some is obtained from dietary intake.The synthesis of cholesterol takes place in the cytoplasm and the endoplasmic reticulum(ER)of hepatocytes(the major liver cell types)and starts with one molecule of acetyl-CoA.

关 键 词：CHOLESTEROL INTAKE cancer 

分 类 号：R73[医药卫生—肿瘤]