青少年及儿童骨肉瘤患者远期预后的影响因素  

Long-term Prognostic Factors of Children with Osteosarcoma in Adolescents and Children

作　　者：王薇[1] 刘艳[1] 管雪红 WANG Wei;LIU Yan;GUAN Xuehong(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第一附属医院,450000

出　　处：《实用癌症杂志》2022年第3期498-500,共3页The Practical Journal of Cancer

基　　金：河南省自然科学研究计划项目(编号:142102310139)。

摘　　要：目的分析青少年及儿童骨肉瘤患者远期预后的影响因素。方法选取青少年及儿童骨肉瘤患者65例,统计3年生存率,收集不同预后患儿性别、年龄、肿瘤部位、Enneeking分期、卡氏评分(KPS)、有无远处转移等资料,分析预后影响因素。结果本组65例患儿中,3年生存46例,死亡19例,生存率70.77%(46/65)。Enneeking分期、KPS评分、有无远处转移、术后辅助化疗次数是青少年及儿童骨肉瘤患者术后3年生存的影响因素(P<0.05)。Logistic回归分析显示,Enneeking分期Ⅲ期、KPS评分<70分、远处转移、术后辅助化疗次数<6次是青少年及儿童骨肉瘤患者术后3年生存的危险因素(P<0.05)。结论Enneeking分期高、KPS评分低、存在远处转移、术后辅助化疗次数少是青少年及儿童骨肉瘤患者远期预后的危险因素,临床可针对性地实施有效干预措施,改善患儿远期预后。Objective To analzye the long-term prognostic factors of children with osteosarcoma.Methods 65 children with osteosarcoma were selected,3-year survival were analyzed,the data of sex,age,tumor location,Enneeking stage,KPS score,distant metastasis were collected.Analyzed the influencing factors.Results Of the 65 patients,46 survived at 3 years and 19 died,with a survival rate of 70.77%(46/65).Enneeking stage,KPS score,presence or absence of distant metastases,and number of postoperative adjuvant chemotherapy were factors influencing 3 years of postoperative survival in adolescent and pediatric osteosarcoma patients(P<0.05).Logistic regression analysis revealed that Enneeking stage,KPS score<70,distant metastasis,and postoperative adjuvant chemotherapy were 6 risk factors for 3 years of postoperative survival in adolescent and pediatric osteosarcoma patients(P<0.05).Conclusion High Enneeking stage,low KPS score,distant metastases and low number of postoperative adjuvant chemotherapy are the risk factors for long-term prognosis in adolescents and pediatric osteosarcoma patients.The effective interventions can be implemented clinically to improve the long-term prognosis of children.

关 键 词：青少年 儿童 骨肉瘤 远期预后 3年生存率 影响因素 

分 类 号：R738.7[医药卫生—肿瘤]