Effect of synoviectomy combined with postoperative radiotherapy on pigmented villonodular synovitis in knee:A meta-analysis  

作　　者：Qi-Zhong Lai Tian-Ye Lin Peng Yang Bing-Lang Xiong Qi-Zhao Zou Kai-Shen Cai Zi-Qi Li Wei He Qing-Wen Zhang 

机构地区：[1]The First Clinical College of Guangzhou University of Chinese Medicine,Guangzhou 510080,China [2]The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510080,China

出　　处：《Journal of Hainan Medical University》2022年第4期37-44,共8页海南医学院学报（英文版）

基　　金：General Project of National Natural Science Foundation of China(No.81873327);Youth Project of National Natural Science Foundation of China(No.81904226)。

摘　　要：Objective:To evaluate the efficacy of synovectomy combined with postoperative radiotherapy in the treatment of pigmented villonodular synovitis compared with only synovectomy in knee. Methods:The related references were searched from SinoMed,CNKI,Wanfang,VIP,PubMed,Embase,Cochrane Library and Web of Science from date of databases establishment to October 2020,and the studies of synovectomy combined with postoperative radiotherapy were screened. According to the type of research,the corresponding evaluation methods were selected for quality evaluation of the literature. RevMan 5.3 software was used for meta-analysis. The primary outcome was recurrence,while the secondary outcomes included complications,excellent and good rate of function of knee,range of motion of knee,Lysholm score,and IKDC score of knee etcetera. Results:A total of 11 articles were included in meta-analysis,with 510 cases,280 in the combined group and 230 in the control group. The results of meta-analysis showed that:(1)The recurrence rate in the combination group was significantly lower than that in the control group,[OR=0.33,95%CI(0.20,0.55),P<0.000 1];(2)The complications in the combined group were higher than that in the control group[OR=2.70,95%CI(1.16,6.31),P=0.02];(3)The excellent and good rate of the combined group was significantly better than that of the control group[OR=2.86,95%CI(1.23,6.64),P=0.01],and it also may be the result of different evaluation criteria of each study;(4)There was no significant difference range of motion[MD=2.96,95%CI(-0.54,6.47),P=0.10],Lysholm score[MD=3.22,95%CI(-0.51,6.96),P=0.09],or IKDC score[MD=2.88,95%CI(-1.07,6.82),P=0.15]in knee between the two groups. Conclusion:The meta-analysis shows that synovectomy combined with radiotherapy can reduce the recurrence rate of pigmented villonodular synovitis in knee,but compared with only operation,there are higher complications. However,the above conclusions need to be verified by long-term follow-up of more high-quality clinical studies.

关 键 词：Pigmented villonodular synovitis KNEE ARTHROSCOPY Open surgery SYNOVECTOMY RADIOTHERAPY META-ANALYSIS 

分 类 号：R73[医药卫生—肿瘤]