Liver sinusoidal endothelial cells-The liver’s gatekeeper  

作　　者：Zi-Bing Qian Qi Zhang Pei-Yun Zeng Zhi-Xiu Zhang Jing Liu 

机构地区：[1]Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China [2]Department of Endocrinology,Gansu Provincial People's Hospital,Lanzhou 730000,China

出　　处：《Journal of Hainan Medical University》2022年第4期67-72,共6页海南医学院学报（英文版）

基　　金：National Natural Science Foundation of China(No.81760151)。

摘　　要：Hepatic sinusoidal endothelial cell(LSECs),as the sinusoidal capillary channel of the liver,is the most abundant non-parenchymal cell group in the liver. LSECs not only forms a barrier in the hepatic sinusoid,but also has important physiological and immunological functions,including filtration,endocytosis,antigen presentation and leukocyte recruitment. It has been clear that LSECs play an important role in maintaining immune homeostasis in the liver and delaying the immune response to acute and chronic liver injury. In this review,we summarize how LSECs affect the immune microenvironment in the liver,and discuss their role in immune-mediated chronic liver disease,carcinogenesis,inflammation and aging process.

关 键 词：Hepatic sinusoidal endothelial cells Immunity Chronic liver disease Inflammation SENESCENCE 

分 类 号：R57[医药卫生—消化系统]