感冒双解颗粒解热作用研究  

Study on the Antipyretic Effects of Ganmaoshuangjie Granules

作　　者：陈良 徐晓琴[1,2,4] 郭玉东 买迪娜[1] 阿吉艾克拜尔·艾萨[1] CHEN Liang;XU Xiaoqin;GUO Yudong;MAI Dina;HAJIAKBER·Aisa(Xinjiang Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Urumqi 830011,China;University of Chinese Academy of Sciences,Beijing 100049,China;Affiliated Traditional Chinese Medicine Hospital of Xinjiang Medical University,Xinjiang Key Laboratory of Processing and Research of Traditional Chinese Medicine y Urumqi 830000,China;Xinjiang Institute of Chinese Materia Medica and Ethnodrug,Urumqi 830002,China;Beijing Institute For Drug Control,Beijing 100035,China)

机构地区：[1]中国科学院新疆理化技术研究所,乌鲁木齐830011 [2]中国科学院大学,北京100049 [3]新疆医科大学附属中医医院,新疆中药炮制研究重点实验室,乌鲁木齐830000 [4]新疆维吾尔自治区中药民族药研究所,乌鲁木齐830002 [5]北京市药品检验所中药成分分析与生物评价北京市重点实验室,北京100035

出　　处：《实验动物科学》2022年第1期70-73,共4页Laboratory Animal Science

基　　金：乌鲁木齐市2019年科技人才项目;新疆地产中药民族药新药研发培育项目(20170208)。

摘　　要：目的研究感冒双解颗粒解热作用。方法采用大鼠干酵母和家兔细菌内毒素解热模型,给予高、中、低剂量的感冒双解颗粒浸膏粉,观察感冒双解颗粒对发热模型动物体温的影响,考察解热作用强度及时程。结果感冒双解颗粒浸膏粉高剂量组(1.7 g浸膏粉/kg)在给药后1.5~4 h能明显抑制干酵母模型大鼠体温升高,降温幅度约为0.7℃,而各剂量组对细菌内毒素模型家兔的体温升高抑制作用不明显。结论感冒双解颗粒对溃烂等炎症引起的体温升高具有一定的解热作用。Objective To study the antipyretic effects of Ganmaoshuangjie granules.Method Rat dry yeast model and rabbit bacterial endotoxin model were used,high,medium and low doses compound of Ganmaoshuangjie granules were given.To observe the effect of cold biolysis granules on the body temperature of febrile model,the intensity of heat release was investigated.Result The high dosage group(1.7 g extract powder/kg)of Ganmaoshuangjie granules was able to significantly inhibit the elevated temperature of the dry yeast model,and cooling rate of about 0.7℃.However,the effect of the dose group on the hypothermia of bacterial endotoxin model was not obvious.Conclusion The Ganmaoshuangjie granules has a certain thermal effect on the temperature rise caused by ulceration and so on.

关 键 词：感冒双解颗粒 干酵母 细菌内毒素 解热 

分 类 号：Q95-3[生物学—动物学]