A scoping review of SARS-CoV-2 and male infertility: Concerns and future prospects  

作　　者：Falah Hasan Obayes AL-Khikani Aalae Salman Ayit 

机构地区：[1]Medical Technique Department,College of Medical Technique,The Islamic University,Babylon,Iraq

出　　处：《Asian pacific Journal of Reproduction》2022年第2期53-61,共9页亚太生殖杂志（英文版）

摘　　要：Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has been detected in the blood,urine,facial/anal swabs,semen,and vaginal discharge;all have been shown to contain SARSCoV-2 RNA.Recent findings have highlighted the prospect of SARS-CoV-2 invading the genital system in addition to other tissues,which might give rise to reproductive concerns.This investigation sheds light on male reproductive tract vulnerability to invasion by SARS-CoV-2 and provides a foundation for further researches into male fertility.Males are infected with COVID-19 at a higher rate than females.As a result,some data suggest that this viral infection might affect the male reproductive system.The probable causes for male genital tract abnormalities in COVID19 are:(1)high expression of angiotensin-converting enzyme 2 in the testes;(2)SARS-CoV-2 infection indirectly induces immune response in the testes;(3)SARS-CoV-2 directly damages male genital cells by virus-receptor binding activity;(4)fever in SARSCoV-2 infected males may cause damages to testicular cells;(5)testosterone level decreased in SAR-CoV-2 infected males;(6)males are more susceptible to COVID-19 than females,which may be due to differences in the physiology of the genital tract.This review seeks to offer some insights into the potential causes of COVID-19 that affect the male reproductive system,as well as future prospect on this issue.

关 键 词：INFERTILITY COVID-19 SARS-CoV-2 Male reproductive system CORONAVIRUS Genital tract abnormalities ORCHITIS 

分 类 号：R73[医药卫生—肿瘤]