Frequency cumulative effect of subthreshold energy laser-activated remote phosphors irradiation on visual function in guinea pigs  

作　　者：Yu-Fei Zhang Xiao-Hong Zhou Rui-Dan Cao Jun-Bo Song Dong-Yu Wei Fu-Jun Duan Wei Wang Zuo-Ming Zhang Tao Chen 

机构地区：[1]Center of Clinical Aerospace Medicine,Air Force Medical University,Xi'an 710032,Shaanxi Province,China [2]The Air Force Hospital from Northern Theater PLA,Shenyang 110092,Liaoning Province,China [3]Ophthalmology,Children's Hospital of Fudan University,National Children's Medical Center,Shanghai 201102,China [4]Basic Medical College,Air Force Medical University,Xi'an 710032,Shaanxi Province,China [5]Department of Aviation Medicine,Air Force Hospital of Southern Theater Command,Guangzhou 510062,Guangdong Province,China [6]Naval Medical Center of PLA,Shanghai 200433,China [7]Department of Aviation Medicine,Xijing Hospital,Air Force Medical University,Xi5an 710032,Shaanxi Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2022年第2期213-220,共8页国际眼科杂志（英文版）

基　　金：Supported by the Key Research Plan of Shaanxi Province,China(No.2018SF-257);the Key Project of Equipment Scientific Research(No.172B02027)。

摘　　要：AIM:To explore the effects of laser-activated remote phosphors(LARP)on visual function in guinea pigs.METHODS:Electroretinogram(ERG)of guinea pigs were observed after LARP irradiation at different frequencies and irradiation times.We evaluated the expression of rhodopsin,β-catenin,connexin36,calretinin,and calbindin in the retina of guinea pigs and measured the density of photoreceptor cells after high-frequency LARP irradiation.RESULTS:After LARP irradiation,the ERG results showed that the amplitude of the dark-adapted 3.0 b-wave of the model eye was lower than that of the control eye after high-frequency irradiation(P<0.05).The expression of rhodopsin,β-catenin,connexin36,calretinin,and calbindin in the retina of guinea pig declined.CONCLUSION:There is frequency cumulative damage effect on the retina that relates to LARP illumination frequency.This has significance for staff visual protection policies under LARP lighting conditions.

关 键 词：IRRADIATION visual function visual protection RETINA 

分 类 号：R77[医药卫生—眼科]