Comparison of pathological findings between patients with relapsed and non-relapsed immunoglobin G4-related disease  

作　　者：Hui Lu Shan Wang Mu Wang Xiaowei Liu Linyi Peng Jiaxin Zhou Jieqiong Li Zheng Liu Xuan Luo Yu Peng Yunyun Fei Yan Zhao Xiaofeng Zeng Ruie Feng Wen Zhang 

机构地区：[1]Department of Rheumatology,Peking Union Medical College Hospital,Chinese Academy of Medical Science and Peking Union Medical College,National Clinical Research Center for Dermatologic and Immunologic Diseases,State Key Laboratory of Complex Severe and Rare Diseases,Beijing 100730,China [2]Department of Pathology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China [3]Department of Stomatology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China [4]Department of Ophthalmology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China

出　　处：《Chinese Medical Journal》2022年第4期465-467,共3页中华医学杂志（英文版）

基　　金：This work was supported by grants from the National Natural Science Foundation of China(Nos.81771757,81771780,82071839);the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(No.NWB20203346);Capital’s Funds for Health Improvement and Research(No.2020-2-4017);Beijing Municipal Science and Technology Commission(No.Z201100005520023)。

摘　　要：Immunoglobin(Ig)G4-related disease(IgG4-RD)is an immune-mediated fibroinflammatory condition characterized by elevated serum IgG4 levels and multi-organ involvement.The characteristic histological findings of IgG4-RD are dense lymphoplasmacytic infiltration,fibrosis,and massive IgG4 positive plasma cells infiltrating the affected tissues.[1]Previous studies have demonstrated various relapse predictors corresponding to demographic,clinical characteristics,laboratory test results,and treatment agents.However,no study has revealed the risk factors of flares in pathology.This study aimed to ascertain whether the pathological characteristics are related to therapeutic outcomes.

关 键 词：IGG4 RELAPSE INVOLVEMENT 

分 类 号：R593[医药卫生—内科学]