Current role of surgery for tuberous sclerosis complex-associated epilepsy  

作　　者：Nicola Specchio Giusy Carfi Pavia Luca de Palma Alessandro De Benedictis Chiara Pepi Marta Conti Carlo Efisio Marras Federico Vigevano Paolo Curatolo 

机构地区：[1]Rare and Complex Epilepsy Unit,Department of Neurosciences,Bambino GesùChildren’s Hospital,IRCCS,Rome,Italy [2]Neurosurgery Unit,Department of Neurosciences,Bambino GesùChildren’s Hospital,IRCCS,Rome,Italy [3]Department of Neurosciences,Bambino GesùChildren’s Hospital,IRCCS,Rome,Italy [4]Child Neurology and Psychiatry Unit,Systems Medicine Department,Tor Vergata University,Rome,Italy

出　　处：《Pediatric Investigation》2022年第1期16-22,共7页儿科学研究（英文）

摘　　要：Tuberous sclerosis complex(TSC)is a rare multisystem,autosomal dominant neurocutaneous syndrome in which epilepsy is the most common of several neurological and psychiatric manifestations.Around two thirds of patients develop drug-resistant epilepsy for whom surgical resection of epileptogenic foci is indicated when seizures remain inadequately controlled following trial of two antiseizure medications.The challenge with presurgical and surgical approaches with patients with TSC is overcoming the complexity from the number of tubers and the multiplex epileptogenic network forming the epileptogenic zone.Data suggest that seizure freedom is achieved by 55%-60%of patients,but predictive factors for success have remained elusive,which makes for unconfident selection of surgical candidates.This article presents three different cases as illustrations of the potential challenges faced when assessing the suitability of TSC patients for epilepsy surgery.

关 键 词：EPILEPSY EVEROLIMUS Imaging PROGNOSTICS SURGERY Tuberous sclerosis complex(TSC) 

分 类 号：R726.5[医药卫生—儿科] R725.9[医药卫生—临床医学]