Clinical Study of Different Immunosuppressive Regimens in Liver Transplant Patients  

作　　者：Lijuan JIA Pai PENG Yongqiang WANG Lili JIA Yaoqin ZHANG Ya'nan ZHAO 

机构地区：[1]Shijiazhuang Medical College,Shijiazhuang 050599,China [2]Affiliated Hospital of Qingdao University,Qingdao 266100,China [3]Hospital of First Mobile Armed Police Corps,Dingzhou 071001,China

出　　处：《Medicinal Plant》2022年第1期60-62,共3页药用植物：英文版

摘　　要：[Objectives]To explore the clinical effect of different immunosuppressive regimens in liver transplant patients.[Methods]The study patients were 147 liver transplant patients who underwent liver transplantation in a hospital and received CNI-based immunosuppression in the first two years after the operation.Both groups were given mycophenolate mofetil+glucocorticoid,and the control group was additional given cyclosporine,and the experimental group was given tacrolimus.Followed up and made a record of the liver and kidney function indicators,blood routine examination,blood sugar,and blood concentration of immunosuppressive drugs in the two groups of patients at 3,6,12,18,and 24 months after the operation,and the clinical pharmacist regularly adjusted the dose of immunosuppressive drugs.The renal function indicators of the two groups were compared:glomerular filtration rate(eGFR)and serum creatinine(Scr)level.[Results]Within 24 months after the operation,the eGFR level in the two groups showed a declining trend,and the Scr level showed a rising trend,indicating a decline in renal function;the renal function of the control group decreased at 3 months after operation,and the difference was significant(P<0.05);the renal function of the experimental group also decreased at 12 months after operation,and the difference was significant(P<0.05).[Conclusions]The TAC based triple immunization regimen can delay the decline of renal function in liver transplant patients,and the efficacy is significantly better than the CsA based triple immunization regimen.

关 键 词：Liver transplant patients TACROLIMUS CYCLOSPORINE 

分 类 号：R73[医药卫生—肿瘤]