改良电休克治疗首发精神分裂症的研究进展  

Research advances of modified electroconvulsive therapy for first-episode schizophrenia

作　　者：李莉 刘超猛[1,2] 任艳萍 杨春林[1,2] 马辛[1,2] Li li;Liu Chaomeng;Ren Yanping;Yang Chunlin;Ma Xin(Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing Key Laboratory of Mental Disorders & The National Clinical Research Center for Mental Disorders, Beijing 100088, China;Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069,China)

机构地区：[1]首都医科大学附属北京安定医院精神科精神疾病诊断与治疗北京市重点实验室&国家精神心理疾病临床医学研究中心,北京100088 [2]首都医科大学人脑保护高精尖创新中心,北京100069

出　　处：《首都医科大学学报》2022年第2期249-253,共5页Journal of Capital Medical University

基　　金：首都卫生发展科研专项(2018-3-1171);北京市科学技术委员会科技重大专项(D171100007017001)。

摘　　要：改良电休克治疗(modified electroconvulsive therapy,MECT)作为临床上常用的物理治疗手段之一,被推荐用于精神分裂症阳性症状急性加重或患有紧张症的患者。首发精神分裂症(first-episode schizophrenia,FES)通常起病于青春期或成年早期,FES预后的好坏对患者后期的人格塑造及社会关系维护至关重要。本文总结了MECT治疗FES的研究进展,发现MECT治疗FES起效快,在维持期也表现出了长程的治疗效应,且安全性良好。目前关于MECT治疗FES的研究整体质量一般,数量尚不足,结论的可靠性还需要多中心、大样本的随机对照研究进一步加以证实。As one of the commonly used physical therapy methods in clinical practice,modified electroconvulsive therapy(MECT)is currently recommended for patients with acute exacerbations of positive symptoms or catatonia.First-episode schizophrenia(FES)usually begins in adolescence or early adulthood,and the prognosis of FES is crucial to the shaping of the patient's personality and the maintenance of social relationships in the later period.Starting from the mechanism of action,this paper summarized the research progresses in the MECT for FES and found that MECT not only takes effect quickly but also shows long-term therapeutic effect in the maintenance period,with good safety.However,there are not enough studies on MECT treatment for FES at present,and the overall quality of the included studies is plain.The reliability of the conclusions needs to be confirmed by multi-center and large sample randomized controlled studies.

关 键 词：改良电休克 首发精神分裂症 疗效 安全性 作用机制 

分 类 号：R749.3[医药卫生—神经病学与精神病学]