Non-invasive tests of non-alcoholic fatty liver disease  

作　　者：Guanlin Li Xinrong Zhang Huapeng Lin Lilian Yan Liang Grace Lai-Hung Wong Vincent Wai-Sun Wong 

机构地区：[1]Department of Medicine and Therapeutics,The Chinese University of Hong Kong,Hong Kong,China [2]State Key Laboratory of Digestive Disease,The Chinese University of Hong Kong,Hong Kong,China [3]Medical Data Analytics Centre,The Chinese University of Hong Kong,Hong Kong,China

出　　处：《Chinese Medical Journal》2022年第5期532-546,共15页中华医学杂志（英文版）

基　　金：The Chinese University of Hong Kong (project reference 2020.045)。

摘　　要：For the detection of steatosis,quantitative ultrasound imaging techniques have achieved great progress in past years.Magnetic resonance imaging proton density fat fraction is currently the most accurate test to detect hepatic steatosis.Some blood biomarkers correlate with non-alcoholic steatohepatitis,but the accuracy is modest.Regarding liver fibrosis,liver stiffness measurement by transient elastography(TE)has high accuracy and is widely used across the world.Magnetic resonance elastography is marginally better than TE but is limited by its cost and availability.Several blood biomarkers of fibrosis have been used in clinical trials and hold promise for selecting patients for treatment and monitoring treatment response.This article reviews new developments in the non-invasive assessment of non-alcoholic fatty liver disease(NAFLD).Accumulating evidence suggests that various non-invasive tests can be used to diagnose NAFLD,assess its severity,and predict the prognosis.Further studies are needed to determine the role of the tests as monitoring tools.We cannot overemphasize the importance of context in selecting appropriate tests.

关 键 词：Fatty liver Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Liver fibrosis CIRRHOSIS Transient elastography FIBROSCAN Magnetic resonance imaging 

分 类 号：R575.5[医药卫生—消化系统]