The pathogenesis and diagnosis of sepsis post burn injury  

作　　者：Pengju Zhang Bingwen Zou Yih-Cherng Liou Canhua Huang 

机构地区：[1]State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,and West China School of Basic Medical Sciences&Forensic Medicine,Sichuan University,and Collaborative Innovation Center for Biotherapy,No.17 People’s South Road,Chengdu,610041,China [2]Department of Thoracic Oncology and Department of Radiation Oncology,Cancer Center,West China Hospital,Sichuan University,No.37 Guoxue Alley,Wuhou District,Chengdu,610041,China [3]Department of Biological Sciences,Faculty of Science,National University of Singapore,14 Science Drive 4,117543,Singapore

出　　处：《Burns & Trauma》2021年第1期678-693,共16页烧伤与创伤（英文）

基　　金：supported by grants from the National Natural Science Foundation of China(81821002,81790251,81672381);the Guangdong Basic and Applied Basic Research Foundation(2019B030302012);the Science and Technology Department of Sichuan Province(2018RZ0133);the Chengdu Science and Technology Program(2019-YF05-00715-SN).

摘　　要：Burn is an under-appreciated trauma that is associated with unacceptably high morbidity and mortality.Although the survival rate after devastating burn injuries has continued to increase in previous decades due to medical advances in burn wound care,nutritional and fluid resuscitation and improved infection control practices,there are still large numbers of patients at a high risk of death.One of the most common complications of burn is sepsis,which is defined as“severe organ dysfunction attributed to host’s disordered response to infection”and is the primary cause of death in burn patients.Indeed,burn injuries are accompanied by a series of events that lead to sepsis and multiple organ dysfunction syndrome,such as a hypovolaemic state,immune and inflammatory responses and metabolic changes.Therefore,clear diagnostic criteria and predictive biomarkers are especially important in the prevention and treatment of sepsis and septic shock.In this review,we focus on the pathogenesis of burn wound infection and the post-burn events leading to sepsis.Moreover,the clinical and promising biomarkers of burn sepsis will also be summarized.

关 键 词：BURN Infection SEPSIS Septic shock Multiple organ dysfunction syndrome Immune dysregulation HYPERMETABOLISM TRAUMA Biomaker Inflammation 

分 类 号：R57[医药卫生—消化系统]